Abdominal Sepsis, Encephalitis, Pancreatic Diseases, Seizures, Severe Traumatic Brain Injury, Trauma Injury
Conditions
Brief summary
The investigators are suggesting that closed suction systems may reduce the risk of the ventilator - associated pneumoniae (VAP) and the contamination of the closest unanimated surfaces. In 2011 David et al. have shown that closed suction systems might reduce the incidence of the late VAP. Research team is thinking that preventive bundle with closed suction systems can prevent to onset of the VAP. All enrolled patients is randomizing into two groups: control group - conventional suctioning and research group - suctioning with closed suction system.
Interventions
DEVICEClosed suction systems
Closed suction systems are using for prevention of the ventilator-associated pneumoniae
The using of open (conventional) suctioning
Sponsors
Northern State Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* invasive mechanical ventilation beyond 48 hours
Exclusion criteria
* hospital - acquired pneumonia * community - acquired pneumoniae * BMI \> 35 kg/cm2 * pregnancy * tracheostomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of the ventilator - associated pneumoniae (VAP) | Change from Baseline CPIS at 96 hours | Assessment of CPIS, if CPIS equal or more 6 points VAP will be observed |
| Contamination of closet inanimate surfaces | Change from Baseline Microbiology researching at 96 hours | Microbiology researching samples from circuit of a respirator and a bed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | 28 days | Mortality for 28 days of a hospitalization |
| C - reactive protein | Change from Baseline CRP researching at 96 hours | Investigation of a Biomarker of the VAP |
| sTREM 1 | Change from Baseline CRP researching at 96 hours | Investigation of a Biomarker of the VAP |
| Procalcitonin | Change from Baseline CRP researching at 96 hours | Investigation of a Biomarker of the VAP |
| Organ dysfunction | Change from Baseline SOFA at 96 hours | Patient examination with Sequential Organ Function Assessment (SOFA) |
Countries
Russia
Outcome results
None listed