Diagnoses Disease, Sepsis
Conditions
Keywords
sepsis, procalcitonin, MDW
Brief summary
The mortality rate of sepsis remains as high as 30 to 40%. Early diagnosis and treatment of patients with sepsis reduce mortality significantly. The most commonly used biomarkers in clinical practice are C-reactive protein (CRP) and procalcitonin (PCT). In terms of exploring new diagnostic tools of sepsis, monocyte distribution width (MDW) was first reported in 2017. It was reported as part of the white blood cell (WBC) differential count. MDW greater than 20 and abnormal WBC count together were reported to provide a satisfactory accuracy. The area under curve (AUC) in predicting sepsis-2 is 0.852. It was proposed as a novel diagnostic tool of sepsis in the emergency setting. Nonetheless, the performance of MDW compared with the conventional biomarkers remained unknown. The aim of this study was to compare the diagnostic accuracy of MDW and PCT on sepsis in the emergency department.
Interventions
DIAGNOSTIC_TESTMonocyte Distribution Width
Monocyte Distribution Width as part of the CBC result.
Sponsors
Chang Gung Memorial Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Subject Inclusion Criteria * Adult ≥20 years) subjects presenting to the ED with the chief complaints of fever, altered consciousness, hypotension, and dyspnea. CBC with differential testing performed, at presentation as part of their standard medical care. * Subjects who have signed Informed Consent. Subject
Exclusion criteria
* Previously enrolled in this study (i.e. subjects may not be enrolled more than once in this study) * Subjects discharged from the ED \<72 hours * Pregnant women * Subjects not able to understand or sign Informed Consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity and specificity of predicting sepsis and sepsis-3 patients | within 2 hours after patient arrived ED. | MDW, PCT, and other laboratory tests were all obtained at the same time with 2 hours after the patient was admitted to the emergency department (ED). Sensitivity and specificity of different cutoff value were calculated. Best cutoff value will be decided by the perfomance. |
Countries
Taiwan
Contacts
Primary ContactChih-huang Li, MD
Outcome results
None listed