Alzheimer Disease, Parkinson Disease
Conditions
Keywords
Alzheimer, Parkinson, Ketones, medium chain triglycerides, cognition, brain
Brief summary
A two months intervention in which two groups of cognitive disorders, Parkinson and Alzheimer's disease, will receive 50g/day of a commercial MCT supplement combined with supervised aerobic exercise 3 times/week. Cognition and ketones will be assess before and after the intervention, along with endocannabinoids plasma concentrations.
Interventions
DIETARY_SUPPLEMENTBetaquik MCT supplement
50g/day divided in 3. Breakfast, lunch and dinner
Sponsors
Société des Produits Nestlé (SPN)
Université de Sherbrooke
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Alzheimer's or parkinson disease diagnostic * Stable medication associated with the disease * Able to consent * Presence of an accompanying person for the first and last visit. * Ability to read and talk in French
Exclusion criteria
* MMSE \< 20 * MCT or coconut oil supplementation * Coconut allergy * Cannabis, THC or CBD consumption * Excessive alcohol consumption * Physical activity 3x/week * Presence of an metallic object in the body * Impossibility to lay in dorsal decubitus for 40 minutes * Cardiac disease * Any uncontrolled disease that could interfer with the project.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognition | 2 months, evaluation before and after intervention | Measure of cognition with CANTAB |
| Ketones | 2 months, evaluation before and after intervention | Measurement of ketones concentrations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Endocannabinoids | 2 months, evaluation before and after intervention | Endocannabinoids plasma concentration |
Countries
Canada
Outcome results
None listed