Immune Microenvironment, Luminal A, Lymph Node Metastases
Conditions
Brief summary
Luminal type A breast cancer is a type with good clinical prognosis, and the proportion of lymph node metastasis is low, but a small number of patients have more lymph node metastasis when the primary tumor is very small, and the survival is poor, suggesting that this part of Luminal A breast cancer has the different expression of some genes from that of general Luminal A breast cancer, which affects tumor invasion and participates in the occurrence of tumor metastasis. But the mechanism is not clear, especially in the current tumor microenvironment and immune related mechanisms.We want to investigated the relationship of the transcriptional tumor immune microenvironment with early lymph node metastasis among Luminal A type breast cancer.
Interventions
OTHERno intervention
no intervention
Sponsors
Peking University People's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* invasive breast cancer with Luminal A type;T1 with positive lymph node or T2/T3 with negative lymph node
Exclusion criteria
* Missing specimen
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Transcriptional Characterization | 2020-12 | the relationship of the transcriptional tumor immune microenvironment with lymph node metastases in Luminal A breast tumor;Differences in RNA copy numbers of different genes （using IO Panel） between the two groups of patients |
Countries
China
Outcome results
None listed