Bacteriological Study of Acute Follicular Tonsillitis

Bacteriological Study of Acute Follicular Tonsillitis in Patients Attending the ENT Outpatient Clinic of Assiut University Hospital

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04321733

Enrollment

Registered

2020-03-25

Start date

2020-04-30

Completion date

2021-10-31

Last updated

2020-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Follicular Tonsillitis

Brief summary

The objective of the study is to answer the following questions :- 1. Is there an actual failure rate in tonsillitis treatment with amoxicillin clavulanate ? If yes, 2. What is (are) the possible reason(s) to explain it in our locality ?

Detailed description

Tonsillitis is one of the most common diseases in the throat that occurs in the younger age group . The predominant bacteria causing tonsillitis are group A b-haemolytic streptococci (GABHS), which are highly susceptible to the penicillin group of antibiotics. It has been reported in the literature that the rate of penicillin failure has consistently increased from about 7% in the 1950s to almost 40% in the 2000s. Authors propose many reasons to explain such failure rates e.g. the coexistence of oropharyngeal beta-lactamase producing bacteria . Although there were no documented reports, it was observed that there are rising reports of failure in treatment of acute follicular tonsillitis by amoxicillin clavulanate.

Interventions

DRUGAmoxicillin Clavulanate

Intravenous drug intake of our drug.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 60 Years

Healthy volunteers

Inclusion criteria

patients with acute follicular tonsillitis neither younger than five years nor older than 60 years old.

Exclusion criteria

1. Other causes of tonsillitis that do not cause suppuration . 2. Age below five , and above 60 years . 3. Patients who received antibiotic one week before presentation . 4. Immune compromised patients . 5. Patients with quinsy.

Design outcomes

Primary

Measure	Time frame	Description
The sensitivity of the isolated organism to amoxicillin clavulanate according to culture and sensitivity test	Baseline	throat swabs that will be taken from the tonsillar exudate, placed in sterile bottles and brought to the laboratory for Bacteriological culture of the organism and Antibiotic sensitivity tests will be done for the isolated organism(s).

Contacts

Primary ContactMena W Dous, Principal investigator

Dr_manoon@hotmail.com+201277170022

Backup ContactAlaa K Abd El Haleem, Professor of Otolaryngology

+201005534200

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026