The Effect of Entonox on Stages of Labor in Nulliparous Women

The Effect of Entonox on Stages of Labor in Nulliparous Women :a Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04321642

Enrollment

Registered

2020-03-25

Start date

2019-11-01

Completion date

2020-08-31

Last updated

2024-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Duration of Labor, ENTONOX, Nulliparous

Keywords

Entonox, Nulliiparous

Brief summary

This Trial study about The effect of Entonox associated with duration of labor in Active phase and efficacy for relief pain of labor .So investigators start to study up to 14 months

Detailed description

Investigators will enroll participants in 2 groups by randomized . First group will inhale Entonox and the second group not receive any gas . The participants in Entonox group will inhale gas in 4-5 times for each uterine contraction and Nurse will measure blood pressure , O2 saturation ,pain score before use gas . The outcome,investigators study about Apgar score , duration of labor , pain relief in both group,route of delivery and estimated blood loss

Interventions

DRUGEntonox

Entonox gas with mouth piece

DRUGNot receive Entonox

Not receive any gas

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Nulliparity * Age 18 years old or more * Gestational age 37-40+6 wks * Singleton * Cephalic presentation * Cervical dilatation \> 5 cm * Estimated fetal weight 2,500-4,000 gm

Exclusion criteria

* Estimated fetal weight more than 4,000 gm * High risk pregnancy (Hypertension in pregnancy ,Endocrine disorder , autoimmune disorder , epilsepsy etc) * SpO2 \< 95 % * Contraindication for Entonox usage ( Severe head injury , asthma , Pulmonary disease,Otitis media ) * Drug allergy : Metoclopramide , Dimenhydrinate , Pethidine ,Entonox

Design outcomes

Primary

Measure	Time frame	Description
Effect of Entonox for duration of labor	up to 14 months	Study about duration of labor after receive Entonox in active phase of labor

Secondary

Measure	Time frame	Description
Rate of patients who inhaled Entonox for pain relieve	up to 14 months	% of patients relieve pain after inhaled Entonox , Investigators measure by visual analogue scale

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026