Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04321486

Enrollment

4309481

Registered

2020-03-25

Start date

1998-01-01

Completion date

2020-11-30

Last updated

2020-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia, Alzheimer, Electronic Health Records, Hospitalizations, Epidemiology, Comorbidity, United Kingdom, Incidence, Mortality, Cause of Death

Brief summary

The trajectory of dementia patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the dementia incidence, mortality and case-fatality, we implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident dementia.

Interventions

OTHERThe study does not have an intervention, but observe the dementia incidence of the UK disease-free population.

The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* We identify individuals aged 30 years or older and registered in the current primary care practice for at least one year.

Exclusion criteria

* Individuals are excluded if they had a prior history of dementia before study entry.

Design outcomes

Primary

Measure	Time frame
Incidence and mortality of dementia	Jan 1st 1998 - May 31st 2016

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026