Outcomes and Prognostic Factors in COVID-19

Conditions

COVID-19, Critical Illness, Elderly Patients, Old Age, Survival

Keywords

COVID-19, Elderly patients

Brief summary

The primary aim is to study the short-term outcome of elderly ICU patients (≥ 70 years) suffering from COVID-19 using a multicenter and multi-national approach. The secondary aim is to investigate the properties of a simple frailty scale in this cohort, and in particular if this is an instrument that can be used for outcome prediction in this group. In addition, various other parameters of potential relevance for older critically ill patients will be studied.

Detailed description

The study started in March 2020 and included until summer 2021 nearly 4000 patients. Several comprehensive analyses were conducted and published. Subsequently, in December 2021 the protocol was slightly changed and recruitment continues in 2022. Data are collected regarding: Pre-Admission life conditions with Frailty (Clinical Frailty Scale, CFSF.R.A.I.L Score); vaccination status; ICU-Admission (e.g. SOFA), ICU-Treatment, Survival (30 day and 3 months). Data are collected electronically through an e-CRF and with baseline documentation of the ICU. The database is located in Denmark, at the Department of Epidemiology, University of Aarhus. Each ICU will only have access through the database of their own patients, and patient ID is not registered (Names, birth-date or social security numbers) so it is in that sense anonymous. The goal is to recruit at up to 400 ICUs that will continuously collect data. The COVIP Study had two different previous recruitment periods. Period 1 (march to May 2020) finished representing the first wave of the pandemic in most countries. The second recruitment period has been defined being from September 1st to December 31st 2020 representing the second wave in most countries. Recruitment in 2021 also continued until the summer without allocating a specific recruitment period. However, the third recruitment period opened January 1st 2022 and is still ongoing.

Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Kristina Fuest, Stefan J. Schaller et al. (21 authors)

Journal of Critical Care2024-12-031 citations

10.1016/j.jcrc.2024.154984

Diabetes mellitus is associated with 90-day mortality in old critically ill COVID-19 patients: a multicenter prospective observational cohort study.

Mayerhöfer T, Klein S, Wernly B, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Artigas A, van Heerden PV, Pinto BB, Schefold JC, Moreno R, Cecconi M, Szczeklik W, Jung C, Joannidis M, COVIP study group.

2023-03-016 citations

10.1007/s15010-023-02001-2

The association of prior paracetamol intake with outcome of very old intensive care patients with COVID-19: results from an international prospective multicentre trial.

Baldia PH, Wernly B, Flaatten H, Fjølner J, Artigas A, Pinto BB, Schefold JC, Kelm M, Beil M, Bruno RR, Binnebößel S, Wolff G, Erkens R, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Leaver S, De Lange DW, Guidet B, Jung C, COVIP study group.

2022-12-275 citations

10.1186/s12877-022-03709-w

COVID-19 machine learning model predicts outcomes in older patients from various European countries, between pandemic waves, and in a cohort of Asian, African, and American patients

Behrooz Mamandipoor, Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Jesper Fjølner et al. (18 authors)

PLOS Digital Health2022-11-088 citations

10.1371/journal.pdig.0000136

Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study

Georg Wolff, Bernhard Wernly, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno et al. (29 authors)

Canadian Journal of Anesthesia/Journal canadien d anesthésie2022-08-098 citations

10.1007/s12630-022-02304-2

Noninvasive ventilation in COVID-19 patients aged ≥ 70 years-a prospective multicentre cohort study.

Polok K, Fronczek J, Artigas A, Flaatten H, Guidet B, De Lange DW, Fjølner J, Leaver S, Beil M, Sviri S, Bruno RR, Wernly B, Bollen Pinto B, Schefold JC, Studzińska D, Joannidis M, Oeyen S, Marsh B, Andersen FH, Moreno R, Cecconi M, Jung C, Szczeklik W, COVIP Study Group.

2022-07-2214 citations

10.1186/s13054-022-04082-1

The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19.

Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Baldia PH, Binneboessel S, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Kondili E, Marsh B, Wollborn J, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C, COVIP study group.

2022-03-1818 citations

10.1186/s13613-022-00996-9

Association of Chronic Heart Failure with Mortality in Old Intensive Care Patients Suffering from Covid-19

Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Jesper Fjølner, Antonio Artigas et al. (29 authors)

ESC Heart Failure2022-03-107 citations

10.1002/ehf2.13854

Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation

Christian Jung, Behrooz Mamandipoor, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly et al. (28 authors)

JMIR Medical Informatics2022-01-317 citations

10.2196/32949

Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients: prospective observational study in European intensive care units

Kamil Polok, Jakub Fronczek, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet et al. (24 authors)

British Journal of Anaesthesia2021-11-2827 citations

10.1016/j.bja.2021.11.027

Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe.

Jung C, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M, Joannidis M, Oeyen S, Zafeiridis T, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Flaatten H, , COVIP Study Group.

2021-09-2321 citations

10.1186/s13054-021-03739-7

Early evaluation of organ failure using MELD-XI in critically ill elderly COVID-19 patients

Raphael Romano Bruno, Bernhard Wernly, Johanna Hornemann, Hans Flaatten, Jesper Fjølner et al. (30 authors)

Clinical Hemorheology and Microcirculation2021-08-319 citations

10.3233/ch-219202

Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe

Christian Jung, Hans Flaatten

2021-08-25

10.5281/zenodo.5466937

Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients.

Bruno RR, Wernly B, Flaatten H, Fjølner J, Artigas A, Bollen Pinto B, Schefold JC, Binnebössel S, Baldia PH, Kelm M, Beil M, Sigal S, van Heerden PV, Szczeklik W, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Wollborn J, Arche Banzo MJ, Fuest K, Marsh B, Andersen FH, Moreno R, Leaver S, Boumendil A, De Lange DW, Guidet B, Jung C, COVIP Study Group.

2021-08-2136 citations

10.1186/s13613-021-00911-8

The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study.

Jung C, Flaatten H, Fjølner J, Bruno RR, Wernly B, Artigas A, Bollen Pinto B, Schefold JC, Wolff G, Kelm M, Beil M, Sviri S, van Heerden PV, Szczeklik W, Czuczwar M, Elhadi M, Joannidis M, Oeyen S, Zafeiridis T, Marsh B, Andersen FH, Moreno R, Cecconi M, Leaver S, Boumendil A, De Lange DW, Guidet B, COVIP study group.

2021-04-19116 citations

10.1186/s13054-021-03551-3

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

70 Years to No maximum

Inclusion criteria

1. Age \> 70 years 2. ICU-Admission 3. Infection with SARS-CoV-2

Exclusion criteria

1\. Age \<70 years

Design outcomes

Primary

Measure	Time frame
Survival	up to 30 days

Secondary

Measure	Time frame	Description
Frailty	pre-admission	Frailty will be measured by using the Clinical frailty scale (CFS) a global clinical measure of fitness and frailty in elderly people (1=very fit to 9= terminally ill)

Countries

Denmark, France, Germany, Norway

Contacts

Primary ContactChristian Jung, MD

contact@vipstudy.org+2118118800

Backup ContactRaphael Bruno, MD

covip@med.uni-duesseldorf.de+2118118800

Outcome results