Metabolic Syndrome
Conditions
Brief summary
The main aim of this study is to determine the effect of the addition of medium chain triglycerides to a mixed macro nutritional meal on postprandial macronutrients oxidation (i.e. fat oxidation, carbohydrate oxidation, change in respiratory quotient, peak respiratory quotient, etc.).
Detailed description
A mixed meal characterized by a high quantity of carbohydrates could develop an increment in the postprandial carbohydrate oxidation. Medium chain triglycerides could be absorbed and metabolized immediately. It is plausible that its addition to a mixed meal unchains the decrement in the carbohydrate oxidation and increment in fat oxidation. If this hypothesis it is correct, its lower postprandial carbohydrate oxidation could develop a higher postprandial exposure to hyperglycemia, being of clinical interest. 20 young adults will be randomized into two conditions (experimental and control conditions) with 7 days of separation between conditions. Each evaluation day will conform to the following tests: 1. Basal metabolic rate assessment through indirect calorimetry. 2. Intake of the corresponding mixed meal (experimental or control) 3. Postprandial nutrient oxidation and energy expenditure through indirect calorimetry 4. Blood samples assessment in 9 time points during the evaluation day. 5. Post-prandial sensations related to appetite in 11 time points during the evaluation day
Interventions
DIETARY_SUPPLEMENTMixed meal with medium chain triglycerides
Mixed macronutrient liquid meal (1.6kcal/ml, 15% protein, 47% carbohydrates, 35% fat, 3% fiber) with medium chain triglycerides (3g/100 kcal). An amount with energy supply equivalent to their 50% basal metabolic rate.
DIETARY_SUPPLEMENTMixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides
Mixed macronutrient liquid meal (1.6kcal/ml, 15% protein, 47% carbohydrates, 35% fat, 3% fiber) without medium chain triglycerides (replaced it with long chain triglycerides). An amount with energy supply equivalent to their 50% basal metabolic rate.
Sponsors
Universidad de Granada
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Crossover Assignment
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male or female * Ages 18-30 years * BMI: 18-27.5 kg/m2 * Stable weight over the last 3 months (body weight changes\<35kg) * Participant must be capable and willing to provide consent, understand
Exclusion criteria
, instructions and protocols.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-prandial nutrient oxidation | 4 hours | Fat or carbohydrate oxidation measured by indrect calorimetry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Post-prandial blood glucose concentrations | 4 hours | Measures of blood glucose concentrations |
| Post-prandial blood insulin concentrations | 4 hours | Measures of blood insulin concentrations |
| Post-prandial blood non-esterified fatty acid concentrations | 4 hours | Measures of blood non-esterified fatty acid concentrations |
| Post-prandial blood tryglicerides concentrations | 4 hours | Measures of blood tryglicerides concentrations |
| Post-prandial blood glycerol concentrations | 4 hours | Measures of blood glycerol concentrations |
| Post-prandial blood lactate concentrations | 4 hours | Measures of blood lactate concentrations |
| Post-prandial energy expenditure | 4 hours | Measured by indrect calorimetry |
| Post-prandial sensations related to appetite | 4 hours | Measured by visual analogue scales (VAS). Score ranging from 0 to 100mm. Higher values mean the most positive rating, while lower values mean the most negative rating. |
| Post-prandial blood cholesterol concentrations | 4 hours | Measures of blood cholesterol concentrations |
Countries
Spain
Contacts
Primary ContactJonatan Ruiz Ruiz, Dr.
Backup ContactLucas Jurado Fasoli, PhD student
Outcome results
None listed