Glucose Intolerance
Conditions
Brief summary
The main aim of this study is to determine the inter-day reliability, by using indirect calorimetry, of the post-prandial macronutrient oxidation and energy expenditure after consuming oral glucose load solution.
Detailed description
The maintenance of blood glucose concentrations and the oxidation of carbohydrate after consuming carbohydrate is related with a low risk of mortality and morbidity from cardiometabolic diseases. The oral glucose tolerance test is a diagnostic test widely used in the clinical field. However, its inter-day reliability has not been deeply studied. Therefore, it is of clinical interest to study the inter-day reliability of the diagnostic test oral glucose tolerance test using indirect calorimetry and monitoring the response of the glucose levels. 20 young adults will undergo two trials visit with 7 days of separation between conditions. Each evaluation day will conform to the following tests: 1. Basal metabolic rate assessment through indirect calorimetry. 2. Basal heart rate variability through heart rate monitor. 3. Intake of the corresponding glucose load solution. 4. Postprandial nutrient oxidation and energy expenditure assessment through indirect calorimetry 5. Glucose monitoring through Glucose meter.
Interventions
DIAGNOSTIC_TESTOral glucose tolerance test
Participants will ingest 75g anhydrous glucose dissolved in a volume of 200mL of water (NUTER.TEC GLUCOS, Subra, Toulouse, France).
Sponsors
Universidad de Granada
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male or female * Ages 18-30 years * BMI: 18-27.5 kg/m2 * Stable weight over the last 3 months (body weight changes\<35kg) * Participant must be capable and willing to provide consent, understand
Exclusion criteria
, instructions and protocols.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inter-day reliability, 7 days apart, in post-prandial nutrient oxidation | 7 days | Reliability |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inter-day reliability, 7 days apart, in post-prandial energy expenditure | 7 days | Reliability |
| Inter-day reliability, 7 days apart, in glucose levels | 7 days | Reliability |
Other
| Measure | Time frame | Description |
|---|---|---|
| • Reliability of the O2 and CO2 metabolic cart sensors by pure gases infusions using a high-precision mass-flow controllers | Immediately after the participants' gas exhange measurements | o Inter-day reliability of gas composition (O2 and CO2) measurement by the Omnical® assessed by comparison with a high-precision mass-flow controllers. |
Countries
Spain
Contacts
Primary ContactJonatan Ruiz Ruiz, Dr.
Backup ContactJuan Manuel Alcantara, PhD student
Outcome results
None listed