Obesity, Childhood
Conditions
Keywords
micronutrients, obesity, school-age children, milk proteins
Brief summary
Milk proteins and micronutrients could be beneficial in the prevention and treatment of obesity. The objective was to evaluate a supplement with milk proteins and multivitamins and minerals with nutrition education on anthropometry, body composition, micronutrient status, blood pressure, lipid profile, systemic inflammation, leptin and insulin resistance in obese children at baseline and after 6 months.
Detailed description
Obese children were selected in elementary schools from 5 rural communities of the State of Querétaro. One hundred fifty two obese children (Z-score \>2 standard deviations) aged 6-11y were randomly assigned to receive one of two treatments: 1) 237mL/day of milk proteins and multiple micronutrients supplement (MPMS) plus Nutrition Education (NE) program or 2) NE alone for 24 weeks. Children in both groups were evaluated at baseline and 6 months after treatment initiated. At both times the following variables were evaluated: Visit 1 (Screening): Mothers and parents received oral and written information regarding all aspects of the study. Informed consent, medical history, demographic information, weight and height were obtained. Visit 2 (Clinical Laboratory testing): A blood preasure and sample was taken by an specialist. Blood test included Glucose, total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol, Tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10), C reactive protein, insulin and leptin. Visit 3 (Nutrition Clinic at UAQ): body composition was determined by DEXA. The NE were given at Nutrition Clinic and school to the children's parents each week.
Interventions
DIETARY_SUPPLEMENTSupplement with micronutrients
Obese children were divided in 2 groups. A group received the supplement plus nutrition education and other group was a control, only received nutrition education.
OTHERNutrition education
Group received nutrition education program during 6 months
Sponsors
NUCITEC S.A. de C.V.
Universidad Autonoma de Queretaro
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Control group received only nutrition education and treated group received nutrition education plus a supplement with milk protein and micronutrients.
Eligibility
Sex/Gender
ALL
Age
6 Years to 11 Years
Healthy volunteers
Yes
Inclusion criteria
* Children with obesity (BMI\>30) * Aged: 6 to 11 years * Both sex * Parents accepted to participate and signed informant consent
Exclusion criteria
* Children with dyslipidemia * Metabolic disease * Hypertension * Physical disability * Using vitamins and minerals supplements and/or receiving treatment for obesity during the last 3 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total body fat | baseline to 6 months | change in fat |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HDL | Baseline to 6 months | change in HDL |
| LDL | baseline to 6 months | change in LDL |
| Triglycerides | baseline to 6 months | change in triglycerides |
| Glucose | baseline to 6 months | change in glucose |
| Interleukin 6 (IL-6) | baseline to 6 months | Change in IL-6 |
| Interleukin 10 (IL-10) | baseline to 6 months | change of IL-10 change in IL-10 |
| C reactive protein (CRP) | baseline to 6 months | change of CRP |
| Bone mineral density (BMD) | baseline to 6 months | change in BMD |
| Total cholesterol | Beaseline to 6 months | Change in total cholesterol |
| Zinc levels | baseline to 6 months | Change in zinc levels |
| Iron levels | baseline to 6 months | Change in iron levels |
| A vitamin levels | baseline to 6 months | change in A vitamin levels |
| C vitamin levels | baseline to 6 months | change of C vitamin levels |
| D vitamin levels | baseline to 6 months | change in D vitamin levels |
| E vitamin levels | baseline to 6 months | change of E vitamin levels |
| Systolic blood pressure (SBP) | baseline to 6 months | change in SBP |
| Diastolic blood pressure (DBP) | baseline to 6 months | change in (DBP) |
| Body mass index (BMI) | Baseline to 6 months | Change in BMI |
Outcome results
None listed