Stroke
Conditions
Brief summary
The study focusses on utilizing neuroimaging modalities, including Electroencephalography (EEG) and Functional Magnetic Resonance Imaging (fMRI) to study the impact of non-invasive brain stimulation on the prefrontal cortex during a cognitive task.
Detailed description
In this study, a total of 40 subjects will be randomly assigned to 2 groups i.e. experimental and sham. Conventional transcranial direct current stimulation (c-tDCS) and high-definition transcranial direct current stimulation (HD-tDCS) will be used to stimulate the prefrontal cortex of the brain. EEG and fMRI will be collected before, during and after stimulation to understand the impact of stimulation on brain dynamics. The investigators hypothesize that the stimulation of the prefrontal cortex will improve performance during cognitive tasks along with changes in the neural processing detected by neuroimaging modalities.
Interventions
Transcranial Direct Current Stimulation (tDCS) is a non-invasive brain stimulation device that can excite or inhibit the brain activity depending on the stimulation protocol. It has mainly two variants including conventional c-tDCS and High-Definition HD-tDCS.
Sponsors
Chinese University of Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Right Handedness, * Age \> 18
Exclusion criteria
* History of any other neurological disease, * Any psychological or psychiatric disease, * Significant visual or auditory impairments, * tDCS contraindications including implanted metallic or electronic devices, seizures or convulsions, and pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reaction Time (RT) | 1 hour | Reaction time of the subject during a cognitive task would be a measure to assess changes in performance due to stimulation |
| Concentration Rate | 1 hour | The percentage of accurate responses during the cognitive task within the stipulated time will be calculated to see an impact on concentration after stimulation |
| Event related potential latency and amplitude | 1 hour | Changes in latency and amplitude of event related potentials including P300 & N200 would be used as neural marker to understand cognitive processing in the brain. |
| Functional Magnetic Resonance Imaging (fMRI) | 1 hour | Changes in fMRI connectivity |
Countries
Hong Kong
Contacts
Primary ContactRaymond Tong, PhD
Outcome results
None listed