the Association Between Obesity and Early Puberty

Polymorphisms in Obesity-related Genes Are Associated With Risk of Early Puberty in Han Chinese Girls

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04317014

Enrollment

628

Registered

2020-03-20

Start date

2016-09-01

Completion date

2019-06-04

Last updated

2020-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early Puberty

Brief summary

childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.

Detailed description

the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

7 Years to 10 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion criteria

* The participants who were not the first visit to the hospital and had been treated before. * The participants who were with endocrine disorders.

Design outcomes

Primary

Measure	Time frame	Description
genotypes of SNPs in the obesity-related genes	3 months	the obesity-related SNPs in the LRRN6C, MAF, CYP27A1 and ETV5 genes are selected and the genotypes of these SNPs are determined with a MassARRAY system.

Outcome results