SARS-CoV-2 Pneumonia
Conditions
Brief summary
The emergence of SARS-CoV-2 is currently engaging and consuming most of resources of efficient healthcare systems in Europe, and several hospitals are currently experiencing a shortage of ICU beds for critically-ill patients with SARS-CoV-2 pneumonia. A risk stratification based on clinical, radiological and laboratory parameters seems necessary in order to better identify those patients who may need ICU admission and/or those who may benefit from a prompt antiviral therapy
Detailed description
The study will compared patients with and without respiratory failure in order to find risk factors for need for ICU admission. A simple score based on risk factors will be created from a multicenter Italian cohort and validated in a multicenter international cohort.
Interventions
None listed
Sponsors
University of Bologna
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Hospitalized patients with microbiologically confirmed diagnosis of SARS-CoV-2 infection * Age \> 17 years
Exclusion criteria
* Invasive mechanical ventilation within 12 hours from hospital admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory failure | 14 days | Composite of ICU admission or SpO2\<92% with 100% FiO2 of oxygen treatment (reservoir mask or CPAP or NIV), respiratory rate \>30 bpm, respiratory distress |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurence of bacterial superinfection | 14 days | Incidence of bacterial superinfection among ventilated patients with SARS-CoV-2 pneumonia |
Countries
Italy
Outcome results
None listed