Gut Microbiota, Postoperative Delirium
Conditions
Brief summary
The study is a case-controlled observational trial. Sixty patients will be divided into 2 groups depending on whether postoperative delirium or not. This study aims to characterise the gut microbiota in patients undergoing gastrointestinal surgery with postoperative delirium. The CAM-ICU (Confusion Assessment Method for Intensive Care Unit) was used for delirium assessment.
Detailed description
The study is a case-controlled observational trial. Sixty patients will be divided into 2 groups depending on whether postoperative delirium or not. This study aims to characterise the gut microbiota in patients undergoing gastrointestinal surgery with postoperative delirium. The CAM-ICU (Confusion Assessment Method for Intensive Care Unit) was used for delirium assessment. General anesthesia was induced as follows: 0.3 mg kg-1 intravenous (IV) etomidate, 2 mg IV midazolam, 0.4 μg kg-1 IV sufentanil, and 0.2 mg kg-1 IV cisatracurium. Anesthesia was maintained with an end-tidal concentration of 2-3 vol% sevoflurane and 0.2-0.3 μg kg-1h-1 sufentanil to maintain the bispectral index between 40 and 60.
Interventions
DRUGGeneral anesthetic
General anesthesia was induced as follows: 0.3 mg kg-1 intravenous (IV) etomidate, 2 mg IV midazolam, 0.4 μg kg-1 IV sufentanil, and 0.2 mg kg-1 IV cisatracurium. Anesthesia was maintained with an end-tidal concentration of 2-3 vol% sevoflurane and 0.2-0.3 μg kg-1h-1 sufentanil to maintain the bispectral index between 40 and 60.
Sponsors
China Medical University, China
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* 1\. ethnic Chinese; * 2\. age, 18 to 80 years old; * 3\. American Society of Anaesthesiologists (ASA) physical status I or II; * 4\. required Gastrointestinal Surgery
Exclusion criteria
* Cognitive difficulties * Partial or complete gastrectomy * Previous esophageal surgery * Previous treated by radiotherapy or surgery * Inability to conform to the study's requirements * Deprivation of a right to decide by an administrative or juridical entity * Ongoing participation or participation in another study \<1 month ago
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Characterisation of Gut Microbiota | from baseline to postoperative 72 hours | this study will characterise gut microbiota in 2 groups of 30 patients |
Countries
China
Contacts
Primary ContactWen-fei Tan
Outcome results
None listed