Mechanisms for Organ Dysfunction in Covid-19

Conditions

Acute Kidney Injury, Acute Respiratory Distress Syndrome, COVID-19, Organ Dysfunction Syndrome, Multiple, Organ Dysfunction Syndrome Sepsis, Septic Shock

Brief summary

The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.

Detailed description

Consenting patients with suspected or verified SARS-COV-2 infection, COVID-19, will undergo daily blood, urine and sputum sampling during their stay in intensive care. Data on organ dysfunction will be collected through the electronic patient journal and electronic patient data management system. The collected samples will be analysed for a panel of potential biomarkers that will be correlated to organ dysfunction and clinical outcome.

Kristin Jona Bjarnadottir, Gaetano Perchiazzi, Caroline Lördal Sidenbladh, Aleksandra Larina, Ewa Wallin et al. (15 authors)

Frontiers in Physiology2024-07-103 citations

10.3389/fphys.2024.1399407

Halvorsen P, Hultström M, Hästbacka J, Larsson IM, Eklund R, Arnberg FK, Hokkanen L, Frithiof R, Wallin E, Orwelius L, Lipcsey M.

2023-10-2110 citations

10.1038/s41598-023-45346-2

Central nervous system biomarkers GFAp and NfL associate with post-acute cognitive impairment and fatigue following critical COVID-19.

Bark L, Larsson IM, Wallin E, Simrén J, Zetterberg H, Lipcsey M, Frithiof R, Rostami E, Hultström M.

2023-08-1222 citations

10.1038/s41598-023-39698-y

Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients.

Perchiazzi G, Larina A, Hansen T, Frithiof R, Hultström M, Lipcsey M, Pellegrini M.

2022-10-255 citations

10.1186/s13054-022-04200-z

Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study

Michael Hultström, Miklós Lipcsey, David Morrison, Tomoko Nakanishi, Guillaume Butler‐Laporte et al. (17 authors)

Critical Care2022-10-2116 citations

10.1186/s13054-022-04203-w

Systemic Human Neutrophil Lipocalin Associates with Severe Acute Kidney Injury in SARS-CoV-2 Pneumonia

Sara Bülow Anderberg, Miklós Lipcsey, Michael Hultström, Ann-Katrin Eriksson, Per Venge et al. (6 authors)

Journal of Clinical Medicine2021-09-1411 citations

10.3390/jcm10184144

A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography.

Pellegrini M, Larina A, Mourtos E, Frithiof R, Lipcsey M, Hultström M, Segelsjö M, Hansen T, Perchiazzi G.

2021-08-049 citations

10.1186/s13054-021-03685-4

Point of care ultrasound screening for deep vein thrombosis in critically ill COVID-19 patients, an observational study.

Galien S, Hultström M, Lipcsey M, Stattin K, Frithiof R, Rosén J, Uppsala Intensive Care COVID-19 Research Group.

2021-06-029 citations

10.1186/s12959-021-00272-z

The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients.

Järhult JD, Hultström M, Bergqvist A, Frithiof R, Lipcsey M.

2021-03-3028 citations

10.1038/s41598-021-86500-y

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Admitted to intensive care * suspected or verified COVID-19

Exclusion criteria

* Pregnancy or breastfeeding * Under-age

Design outcomes

Primary

Measure	Time frame	Description
Acute Kidney Injury	During Intensive Care, an estimated average of 10 days.	KDIGO AKI score

Secondary

Measure	Time frame	Description
30 day mortality	30 days	Death within 30 days of ICU admission
1 year mortality	1 year	Death within 1 year of ICU admission
Chronic Kidney Disease	60 days and 1 year after ICU admission	Development of Chronic Kidney Disease
ARDS	During intensive care, an estimated average of 10 days.	Acute Respiratory Distress Syndrome yes/no
Thromboembolic events	During intensive care	Occurence of thrombosis and/or embolous
ICUAW	During intensive care or after intensive care	Intensive care acquired weakness
SOFA-score	During Intensive Care, an estimated average of 10 days.	Sequential Organ Failure Score as a continuous variable

Countries

Sweden

Outcome results