Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation

Evaluation of Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04316468

Enrollment

Registered

2020-03-20

Start date

2020-03-10

Completion date

2024-04-08

Last updated

2024-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplant Disorder, Reperfusion Injury

Brief summary

Researchers are trying to improve the understanding of systolic function of the heart at the time of liver reperfusion in patients undergoing orthotopic liver transplantation.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age greater than 18 years * Undergoing primary orthotopic liver transplantation

Exclusion criteria

* Redo orthotopic transplantation * Acute or fulminant liver failure * Patient with pre-existing atrial fibrillation or hypertrophic cardiomyopathy * Patients with an abnormal preoperative stress test (EF \<55%, areas of prior infarct, ongoing ischemia)

Design outcomes

Primary

Measure	Time frame	Description
Degree of change in cardiac strain	Up to 1 hour after graft reperfusion	Evaluate the degree of change to cardiac strain using speckle tracking echocardiography

Secondary

Measure	Time frame	Description
Pattern of right and left ventricular strain	Up to 5 hours from the time of surgery start	Describe the pattern of right and left ventricular strain throughout the course of orthotopic liver transplantion.

Countries

United States

Outcome results