The Effect of Periodontal Treatment on Stress and Pregnancy Relationship

Relationship of Sex Steroid and Stress Markers in Saliva and Gingival Crevicular Fluid With Pregnancy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04315532

Enrollment

Registered

2020-03-19

Start date

2016-04-30

Completion date

2016-11-30

Last updated

2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy Gingivitis

Keywords

Stress

Brief summary

There is a relationship between stress and pregnancy gingivitis. This relationship may be double-sided.

Detailed description

The aim of this clinical study was to determine the effect of non-surgical mechanical periodontal treatment on sex steroid and stress markers at pregnancy gingivitis. A total of 84 subjects; 22 pregnant women with gingivitis (group 1) and 25 pregnant women with periodontal healthy (pregnant group), group 2), 22 non-pregnant women with gingivitis (group 3) and 15 non-pregnant women with periodontal healthy (non-pregnant group), group 4) participated in this study. Clinically, plaque index, gingival index, and probing pocket depth were measured at baseline and after therapy.

Interventions

OTHERNon-surgical periodontal treatment

Non-surgical periodontal treatment was performed for pregnant and non-pregnant gingivitis patients. Gingival crevicular fluid (GCF) and saliva samples were taken from all patients baseline and after 8 weeks.

OTHERSaliva samples

Saliva samples were taken from patients for the evaluation of sex steroid and stress markers baseline and after 8 weeks.

OTHERGCF samples

GCF samples were taken from patients for the evaluation of stress markers baseline and after 8 weeks.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

24 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* being between the ages of 24-50 * being pregnant for 23-30 weeks (for pregnant individuals) * not smoking.

Exclusion criteria

* using antimicrobial or anti-inflammatory therapy within the previous 3 months, * having systemic disease, * having periodontitis, * having deep caries lesions, and remnant roots and * having lactation

Design outcomes

Primary

Measure	Time frame	Description
Dehydroepiandrosterone (DHEA)	Baseline and after 8 weeks	The changes in DHEA levels within 8 weeks. Higher values represent a worse outcome. The decrease in DHEA levels is expected after periodontal treatment.
estrogen	Baseline and after 8 weeks	The changes in estrogen levels within 8 weeks. Higher values represent a worse outcome. The decrease in estrogen levels is expected after periodontal treatment.

Secondary

Measure	Time frame	Description
Gingival index	Baseline and after 8 weeks	The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026