Body Composition, Muscle Damage, Muscle Strength, Oxidative Stress, Resistance Training
Conditions
Keywords
Oxidative Stress, Muscle Strength, Resistance Training, Antioxidants
Brief summary
Thirty active male and female athletes will be recruited for the study. Subjects will be examined at baseline for VO2max performance. Subjects will then be stratified and randomly divided equally (50% - 50%) into an Oceanix (supplemental) or placebo condition such that baseline VO2max match. Once randomization, subjects will be baseline tested for multiple measures of muscle force capacity, muscle soreness, immune function, and endocrine function. Upon completion of baseline testing, subjects will all complete a one-day, cross-training course in Tampa, Florida. The training course is known to be extremely vigorous and causes significant muscle damage. Subjects will then be retested for muscle function at 24, and 48 hours following the course. At 24- and 48-hours subjects will be asked to repeat a simulated time trial race. In this way, we will measure repeated race performance, recovery from intense exercise, muscle damage from exercise, and immune function during multiple races.
Interventions
OTHERCross Training Course
One day of a supervised, whole body, cross-training course that is meant to produce muscle damage and soreness.
DIETARY_SUPPLEMENTOceanix
Ingredient contains highly active antioxidant enzymes, including superoxide dismutase (SOD), as well as essential fatty acids, vitamins, amino acids and minerals.
Sponsors
Lonza Ltd.
Applied Science & Performance Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Double-Blind, parallel, randomized, placebo-controlled trial.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and females age 18 to 45 years old * At least one year of cross training experience (i.e. 3 days/week)
Exclusion criteria
* BMI of 30 or more kg/m² * Any allergies to fish, shellfish, algae, or seaweed are excluded from participation * Have any cardiovascular, metabolic, or endocrine disease * Undergone surgery that affects digestion and absorption * Smoking * Drink heavily (\> 7 and \> 14 drinks per week for women and men, respectively) * Women who are pregnant or planning to be pregnant * Taking medication to control blood pressure, lipids, and blood glucose * Have taken or currently taking anabolic-androgenic steroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Perceived Soreness Scale | Baseline, 1 Day of Cross-Training Course, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Assessed through a visual analog scale numbered 0 to 10 with visual descriptors. |
| Changes in One(1) Mile Timed Run | Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Experimental outcome assessing how quickly a 1 mile run can be completed. |
| Changes in Perceived Recovery Status (PRS) | Baseline, 1 Day of Cross-Training Course, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Assessed through a visual analog scale (modified Borg Scale) numbered 0 to 10 with visual descriptors. |
| Changes in Rating of Perceived Exertion (RPE) | Baseline, 1 Day of Cross-Training Course, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Assessed through a visual analog scale numbered 0 to 10 with visual descriptors. |
| Changes in muscle strength | Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Assessed by isometric mid-thigh pull. |
| Changes in muscle power | Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Assessed through ground reaction forces during countermovement and squat jumps on a force plate. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Creatine Kinase | Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Experimental outcome examining creatine kinase in fasted whole blood samples. This is biomarker an indirect measure of muscle damage. |
| Cortisol | Baseline, 24-Hour Post Cross-Training Course, 48-Hours Post Cross-Training Course. | Experimental outcome examining the concentration of cortisol in fasted saliva samples. |
Other
| Measure | Time frame | Description |
|---|---|---|
| VO2max | Baseline | Assessment of VO2max to determine fitness level and use as basis for randomization. |
Countries
United States
Outcome results
None listed