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Lateral Neck Lymph Node Mapping in Thyroid Cancer

Lateral Neck Lymph Node Mapping in Papillary Thyroid Carcinoma

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04312087
Enrollment
250
Registered
2020-03-18
Start date
2016-08-01
Completion date
2022-12-31
Last updated
2020-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Cancer

Keywords

thyroid cancer, lateral neck lymph node, lymph node mapping, neck dissection, sentinel lymph node

Brief summary

This study includes papillary thyroid cancer patients who have unpalpable lateral neck lymph nodes but suspicious on ultrasound and/or CT. Carbon nanoparticles is used as the tracer for lateral neck lymph node mapping.

Interventions

PROCEDURELateral neck sentinel lymph node biopsy

Lateral neck sentinel lymph node biopsy is performed in all patients in Arm B.

PROCEDUREModified lateral neck lymph node dissection

Modified lateral neck dissection (compartment II-V) is performed in all patients in Arm A, and some of the patients in Arm B (according to sentinel lymph node biopsy results).

PROCEDURESuper selective lateral neck lymph node dissection

Super selective lateral neck lymph node dissection is performed in some of the patients in Arm B (according to sentinel lymph node biopsy results).

Sponsors

Fudan University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
14 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Newly diagnosed papillary thyroid cancer * The maximum diameter of the thyroid cancer \<3 cm with enough normal thyroid tissue for tracer injection * Unpalpable lateral neck lymph nodes * Ultrasound and CT showed suspected lateral neck lymph nodes \<2 cm

Exclusion criteria

* Previously treated thyroid cancer * High risk thyroid cancer (e.g. with severe extra-adenial invasion or extensive lymph node metastasis or poorly differentiated thyroid cancer) * Patients with distant metastasis

Design outcomes

Primary

MeasureTime frameDescription
Lymph node counts1 month after surgeryDyed versus undyed lymph node counts in lateral neck compartments

Secondary

MeasureTime frameDescription
Lymph node metastasis rate1 month after surgeryThe rate of lymph node metastasis in lateral neck compartments

Countries

China

Contacts

Primary ContactYu Wang, M.D.
neck130@hotmail.com86-021-64175590
Backup ContactNai-si Huang, M.D.
huangnaisi@fudan.edu.cn86-021-64175590

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026