Impact of Nimodipine on Sublingual Microcirculation in Patients With Hemorrhage - a Prospective Monocentric Observational Study

Impact of Nimodipine on Sublingual Microcirculation in Patients With Subarachnoid Hemorrhage - a Prospective Monocentric Observational Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04311840

Enrollment

Registered

2020-03-17

Start date

2019-11-01

Completion date

2022-12-31

Last updated

2022-09-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subarachnoid Hemorrhage

Keywords

nimodipine, sublingual microcirculation, Side-stream Dark Field imaging

Brief summary

Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.

Detailed description

SAH group - in patients with SAH and documented vasospasms by digital subtraction angiography (DSA) of trans-cranial doppler imaging (TCD) of arteria cerebri media nimodipine is indicated because it is proven to improve the clinical outcome. The disfunction of cerebral microcirculation in rats with SAH has been documented \[1-6\]. Changes in sublingual microcirculation in patients with SAH with documented vasospasms with nimodipine has not been described.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* adulthood * ICU admission * diagnosis of non-traumatic subarachnoid hemorrhage

Exclusion criteria

* inherited coagulation disorder * rheumatic disease * microangiopathy * patient of representative refusal

Design outcomes

Primary

Measure	Time frame	Description
Functional capillary density (FCD)	One week	Parameter describing the perfusion of the microcirculation
Proportion of perfused vessels (PPV)	One week	Parameter describing the perfusion of the microcirculation

Secondary

Measure	Time frame	Description
Vasospasm occurence	One week	Occurence of vasospasms on angiography and/or transcranial Doppler
Circulatory incoherence	One week	Deranged microcirculation in patients on catecholamines

Countries

Czechia

Contacts

Primary ContactDavid Astapenko, M.D., Ph.D.

david.astapenko@fnhk.cz+420608177374

Outcome results