Long-term Prognosis of Patients With Hepatitis B Related Acute-on-chronic Liver Failure

The Investigation on Long-term Outcomes and Prognostic Factors of Patients With Hepatitis B Related Acute-on-chronic Liver Failure

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04310787

Enrollment

300

Registered

2020-03-17

Start date

2020-05-15

Completion date

2024-12-31

Last updated

2024-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute-On-Chronic Liver Failure, Hepatitis B

Keywords

Hepatitis B, Acute-On-Chronic Liver Failure, Prognosis

Brief summary

This study is to investigate the long-term outcomes and prognostic risk factors in patients recovered from hepatitis B virus related acute on-chronic liver failure.

Detailed description

Chronic acute liver failure (ACLF) is a systemic multi-organ failure driven by acute liver injury in the basis of chronic liver disease. The main cause of chronic acute liver failure in China is hepatitis b virus infection.Previous studies on the prognosis of acute on-chronic liver failure mainly focused on the short-term survival rate and the follow-up time was relatively short, while the study on the long-term prognosis of patients with spontaneous recovery of chronic acute liver failure was still lack-ing. Thus,this study mainly retrospectively analyzed the clinical data of patients with chronic hepatitis b related acute liver failure admitted to the department of infectious diseases, the third affiliated hospital of sun yat-sen university, and con-ducted telephone follow-up survey to analyze the long-term prognosis of patients with chronic hepatitis b related acute on-chronic liver failure.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Age from 18 to 65 years old; * The diagnosis consistent with hepatitis b associated chronic acute liver failure； * After hospitalization, the survival time \> 90 days； * The inpatient clinical data are complete.

Exclusion criteria

* Human immunodeficiency virus infection or congenital immune deficiency diseases; * Liver cancer and other tumors, autoimmune liver disease, genetic and metabolic liver disease, or other serious diseases that significantly affect patient survival; * Other conditions that the researchers judged not appropriate for inclusion.

Design outcomes

Primary

Measure	Time frame	Description
adverse events	5 years	Adverse events included decompensated cirrhosis, hepatocellular carcinoma, liver transplantation, and death.

Countries

China

Contacts

Primary ContactLu Wang, Doctor

wanglu910525@163.com+8618814369232

Backup ContactLiang Peng, Doctor

pzp33@hotmail.com+8613533978874

Outcome results