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Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04310514
Enrollment
30
Registered
2020-03-17
Start date
2020-03-09
Completion date
2020-12-31
Last updated
2020-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Keywords

biomarker, albuminuria, uric acid

Brief summary

Rehydration during and after physical exercise is essential to avoid acute kidney injury. Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury. 30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol. Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..

Interventions

DIETARY_SUPPLEMENTFructose/glucose/xylitol/saccharose

1. Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. 2. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. 3. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. 4. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.

Sponsors

Medical University of Gdansk
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* age above 18 years * well-trained soccer players * informed consent

Exclusion criteria

* chronic diseases, especially kidney problems * sigificant changes in urinalysis * creatinine level above normal values

Design outcomes

Primary

MeasureTime frame
Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exerciseafter 60-90 min of pysical exercise
Changes in fractional uric acid excretionafter 60-90 min of pysical exercise

Countries

Poland

Contacts

Primary ContactWojciech Wolyniec, MD,PhD
wolyniecwojtek@gmail.com48 600942998

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 11, 2026