Colorectal Cancer, Colorectal Polyp
Conditions
Keywords
colon capsule endoscopy, ct colonography, colonoscopy, endoscopy
Brief summary
Following European guidelines patients undergoing colonoscopy in one of Odense University Hospitals units will now be offered a colon capsule endoscopy (CCE) in case of incomplete examinations. Patients formerly referred to colonoscopy in general anesthesia or patients who decline colonoscopy after having completed bowel preparation will also be offered a CCE. In our department we have conducted a comparison study documenting that the sensitivity of CCE is superior to CT colonography in both polyps \>9 mm and polyps \>5 mm, which is also supported by an Italian study. The safety and completion rate of CCE following incomplete colonoscopy is confirmed by several studies including one multicenter study and the completion rate is not significantly lower compared to other patient groups. In an incomplete colonoscopy it is always the most oral part of the colon which is not visualized, whereas in CCE, an incomplete investigation will most often have visualized the oral part. By combining incomplete colonoscopy results and incomplete CCE results we can identify patients who have had a complete colon investigation although both investigations were incomplete. Aim: to investigate the quality of CCE and the completion rate in patients who have undergone an incomplete colonoscopy, have completed bowel preparation but declines colonoscopy or have been referred to colonoscopy in general anesthesia.
Interventions
DEVICEColon capsule endoscopy
Endoscopy performed using PillCam2 camera capsule for oral ingestion
Sponsors
Odense University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Incomplete colonoscopy, referral for colonoscopy under general anesthesia or declining colonoscopy after completion of bowel preparation.
Exclusion criteria
* Chrohn's disease with symptoms of stenosis and/or pacemaker
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Complete mucosal visualization combining incomplete investigations | 10 years | By combining results from incomplete colon capsule endoscopy and incomplete colonoscopy we will identify complete combined investigations. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Completion rate of colon capsule endoscopy | 2 years | Total and subgroup completion rates of investigations |
| Safety of colon capsule endoscopy | 1 year | Total and subgroup safety of investigations |
| Quality of colon capsule endoscopy | 1 year | Sensitivity and specificity compared to colonoscopies |
| Economic evaluation | 1 year | Economic analyses and evaluations comparing cost of investigations per patient and per case by investigation type. |
| Patient preference | 2 years | Investigation of patient preferences stratified by demographic characteristics and history of endoscopic procedures |
Countries
Denmark
Contacts
Primary ContactGunnar Baatrup, Prof.
Outcome results
None listed