Brain Tumor
Conditions
Keywords
tumor, tumoral, non-tumoral, pseudotumoral, 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine, FDOPA, positron emission tomography, PET
Brief summary
Background: 3,4-dihydroxy-6-\[18F\]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (PET) can identify well low and high grade brain tumors. However, increased FDOPA uptake has been reported in non-tumoral brain lesions. The aim was to analyse FDOPA-PET in patients with non-tumoral brain lesions and to compare them with patients with (low and high grade) brain tumors. Methods: retrospective analyse. Patients consecutively recruited with suspected primary brain tumor (based on clinical and MRI findings) referred for FDOPA-PET at Nimes university Hospital between June 2015 and June 2019. FDOPA-PET parameters (maximum and mean lesion standardized uptake values \[SUV\] and ratios comparing lesion with different background uptake SUV) and thresholds were analysed in search for those offering optimal discrimination between non-tumoral and tumoral lesions.
Interventions
DIAGNOSTIC_TESTFDOPA-TEP
FDOPA-TEP performed as part of the normal management of a suspected brain tumour
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* presence of defined tumor (histology was required) or non-tumor (diagnosed by histological or other analyses) diagnosis, * clinical and MRI follow-up of \>24 months, * FDOPA-PET scan \<2 months before surgery or stereotactic biopsy (when performed)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FDOPA-TEP | Day 1 | analyse of FDOPA-PET parameters (maximum and mean lesion standardized uptake values \[SUV\] and ratios comparing lesion with different background uptake SUV) |
Countries
France
Outcome results
None listed