Inflammation, Insulin Resistance
Conditions
Brief summary
Red raspberries (Rubus idaeus) are a good source of health enhancing hydrolyzable and condensed tannins, flavonoids, anthocyanins, phenolic acids, rheosmin, potassium, carotenoids, vitamin C, and vitamin K1. Compared to other berries commonly consumed in the US, the health benefits of red raspberries to improve pre-diabetes mellitus (PDM) and type 2 diabetes have never been explored. The clinical study proposed in this project seeks to investigate the protective effect of whole red raspberries against insulin resistance, oxidative stress, and inflammation in PDM and type 2 diabetic patients. The in vitro study proposed in the project will assist in identifying the molecular mechanisms by which whole red raspberry protect islet cells against oxidative stress, insulin resistance and loss of cell function.
Interventions
OTHERRaspberries
Red raspberry smoothies drink
Sponsors
National Processed Raspberry Council
Louisiana State University and A&M College
Pennington Biomedical Research Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* type 2 diabetes
Exclusion criteria
* hypoglycemic agents * Pregnant or nursing a child * chronic medication that does not have a stable dose for greater than one month * anti-inflammatory medication * inflammatory disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) | 2 weeks | Ratio of fasting insulin and glucose |
| A high-sensitivity C-reactive protein (hs-CRP) measured in milligrams per liter | 2 weeks | Measure of systemic inflammation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 3,4-Dihydroxyphenylacetic acid (DOPAC) measured in nanograms per milliliter | 2 weeks | Measure of systemic inflammation |
Outcome results
None listed