Borderline Personality Disorder
Conditions
Brief summary
This study will test the impacts of real time fMRI neurofeedback in patients with Borderline Personality Disorder. This is a pilot study in a small number of people enrolled in clinical programs at Yale New Haven Hospital.
Interventions
BEHAVIORALreal time fMRI neurofeedback
Participants will use real time feedback about their amygdala activity to learn to decrease amygdala activity.
Sponsors
AE Foundation
Central Institute of Mental Health, Mannheim
Yale University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. enrolled in YNHH DBT-IOP 2. must meet specific clinical criteria 3. Inclusion in Experimental group requires participants meet standard safety and quality control requirements for MR scanning 4. For female participants, not pregnant and willing to use a reliable method of contraception during the study
Exclusion criteria
1. IQ\<70 2. vision problem not able to be corrected to normal range 3. medication changes w/in one month 4. Lifetime hx of schizophrenia, schizoaffective d/o, bipolar I disorder. 5. illicit substance use within 7 days of MRI scans 6. taking scheduled opiates 7. taking scheduled benzodiazepines 8. taking scheduled anti-histamines 9. history of seizures 10. significant current or past neurologic illness 11. BMI \< 16.5
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Affective Lability | Baseline compared to the week after intervention | This outcome will be measured by the change in variance of negative emotions measured using ecologic momentary assessment (EMA: surveys sent to participants by smartphone app) repeatedly over a four-day period at each timepoint. The variance between measurements at each timepoint will be calculated, and compared to the other timepoints. There will be 5 negative emotion items at each timepoint, and a higher score indicates more negative emotion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Mean Negative Affect | Baseline compared to the week after intervention | This outcome will be measured by change in mean negative emotion score measured using ecologic momentary assessment (EMA: surveys sent to participants by smartphone app) repeatedly over a four-day period at each timepoint. The mean score at each timepoint will be calculated, and compared to the other timepoints. There will be 5 negative emotion items at each timepoint, and a higher score indicates more negative emotion. |
| Change in Borderline Personality Disorder Symptoms | Baseline compared to the week after intervention | This outcome will be measured by change in Borderline Symptom List (BSL-23) score after neurofeedback. This scale has 23 items, each scored 0-4, and total score is mean item endorsement (sum of all items divided by 23). Higher scores indicate more symptom endorsement. |
| Change in Amygdala Regulation | Baseline compared to the week after intervention | Change in ability to regulate amygdala activity when exposed to provocative images. Amygdala activity is measured as functional magnetic resonance imaging (fMRI) blood oxygen dependant (BOLD) signal |
Countries
United States
Outcome results
None listed