IVF, Ovarian Failure, Premature Ovarian Failure
Conditions
Keywords
ovarian fragmentation, Kawamura, ovarian rejuvenation
Brief summary
This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation. Our aim is to evaluate embryo quality following this procedure in poor ovarian responders and patients with decreased ovarian reserve. Secondary objectives are to assess potential association with the number of oocytes retrieved and pregnancy rates after IVF.
Interventions
PROCEDUREOVARIAN FRAGMENTATION
BILATERAL OVARIAN CORTEX FRAGMENTATION USING LAPAROSCOPIC SCISSORS
Sponsors
Equipo Juana Crespo
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Abdominal surgery need for fertility cause. * Bad embryo quality (\>2 cycles with \< 1 embryo A-B quality. With: A. Poor ovarian responders (previous ≤ 3 retrieved metaphase II oocytes) in a conventional cycle. B. Decreased ovarian reserve (antral follicle count (AFC) ≤ 5 or antiMullerian hormone (AMH) ≤ 0.5 ng/mL). C.Premature ovarian insufficiency according to: * Patients \< 40 years old. * At least 1 year of amenorrhea. * Follitropin serum levels (FSH) \>35 IU/ml in two serum samples separated by at least 1 month. * Estradiol serum levels (E2) \< 20 pg/mL.
Exclusion criteria
1. Clinical/ultrasonographical signs of severe endometriosis ( or endometrioma). 2. Age over 45 years (EMC) 3. Previous ovarian/pelvic surgery. Unilateral oophorectomy. 4. Body Mass Index \> 30 5. Previous gonadotoxic treatment. 6. Genito-urinary tract malformations. 7. Inform consent unsigned.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Embryo quality improvement following ovarian fragmentation (Using ASEBIR Embryo Classification, 2015) | 1 year | Embryo quality improvement following ovarian cortex fragmentation in poor ovarian responders or patients with premature ovarian insufficency using ASEBIR Classification (2015). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| - Follicle growth rate before and after ovarian cortex fragmentation. | 2 months. | Number of antral Follicles in IVF treatment before ovarian fragmentation and after IVF following ovarian fragmentation. |
| - Oocyte number and M-II oocyte (mature oocytes) before and after ovarian cortex fragmentation. | 2 months | — |
| - AntiMullerian hormone (AMH) serum levels before and two months after the procedure. | 2 months. | — |
| - Number of embryos before and after ovarian cortex fragmentation. | 2 months | — |
| - Clinical pregnancy rate following ovarian cortex fragmentation. | 1 year | — |
Countries
Spain
Contacts
Primary ContactANDER MORALES VICENTE
Outcome results
None listed