Anticoagulant, Antiplatelet, Mild Head Injury
Conditions
Keywords
Mild head injury, traumatic brain injury, traumatic intracranial hemorrhage, Anticoagulant, antiplatelet, anticoagulant, antithrombotic, S100β protein, health care cost
Brief summary
Head trauma is a common injury in emergency department. Investigation to search for complication is guided by the clinical examination and the case history, such as taking anti-thrombotics. Cranial computed tomography (CCT) is the gold standard to investigate, and is mandatory in case of antithrombotic drugs. Recently, some biomarkers have proven their utility to rule-out mild head trauma without CCT in the general population. Among these biomarkers, S100β protein has been added in guidelines for mild head trauma. Some studies have found similar data in population taking anticoagulant or antiplatelet drugs. The investigators aim to prove medical utility of S100β protein in population under antithrombotics, by the reduction of CCT use. Then, The investigators hypothesize that the add of S100β protein reduces cost of health care in the management of head injury in that population.
Interventions
OTHERDosage of S100β protein
Dosage of S100β protein
Sponsors
Roche Diagnostics GmbH
Rennes University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Patient ≥ 18 years old * Taking antithrombotic medication (antiplatelet drugs, K vitamin antagonist, direct oral anticoagulants, heparins) * Mild head trauma with Glasgow coma scale ≥ 13 * Trauma occured ≤ 6 hours * Agreeing the participation in the study
Exclusion criteria
* Head injury occured \> 6 hours * Patient \< 18 years old or under juridic protection * pregnant women * polytrauma * Glasgow coma scale ≤ 12 * ancient or actual cerebral ou cutaneous neoplasia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic performances are evaluated by AUC | 1 day | Diagnostic performances of S100β protein in case of mild head trauma for detection of traumatic intracranial lesion in patients under antithrombotic medication compare to cranial computed tomography. |
| Diagnostic performances are evaluated by sensibility, specificity | 1 day | Diagnostic performances of S100β protein in case of mild head trauma for detection of traumatic intracranial lesion in patients under antithrombotic medication compare to cranial computed tomography. |
| Diagnostic performances of S100β protein in case of mild head trauma for detection of traumatic intracranial lesion in patients under antithrombotic medication compare to cranial computed tomography. | 1 day | Diagnostic performances are evaluated by positive and negative predictive values between the strategy with S100β protein compared to the strategy with systematic cranial computed tomography. |
Countries
France
Outcome results
None listed