Coronary Heart Disease, Periodontitis
Conditions
Keywords
Coronary heart disease, peridontitis,
Brief summary
The research question was to investigate whether non-surgical periodontal therapy could reduce cardiovascular risk markers in Coronary heart disease (CHD) patients.
Detailed description
CHD patients or non-CHD with or without periodontitis were included. They were provided with non-surgical periodontal therapy (NSPT). Periodontal parameters and cardiovascular risk markers were measured at baseline and 3 months and 6 months after NSPT.
Interventions
PROCEDUREnon-surgical periodontal treatment
scaling and root planing, home care instruction
Sponsors
Mahidol University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* non-CHD or CHD (at least 50% diameter stenosis in at least one coronary artery and clinically stable with absence of any potentially confounding inflammatory conditions for at least 6 months) * had at least 14 natural teeth excluding third molars
Exclusion criteria
* received anticoagulant drugs * had chronic conditions (e.g. diabetes mellitus, rheumatoid arthritis, malignancy, autoimmune disease) or acute conditions (e.g. trauma, surgery) or medications known to affect systemic inflammatory markers (e.g. antibiotics, immunosuppressive, contraceptives) within 3 months * pregnancy or lactation * presence or history of other infections * periodontal treatment within 6 months * tooth extractions within 2 months prior to the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in C-reactive protein between baseline and 6 months after non-surgical periodontal treatment | 6 months after non-surgical periodontal treatment | change in C-reactive protein level (mg/L) |
| change in fibrinogen level between baseline and 3 months after non-surgical periodontal treatment | 3 months after non-surgical periodontal treatment | change in plasma fibrinogen level (pg/mL) |
| change in activator inhibitor 1 between baseline and 3 months after non-surgical periodontal treatment | 3 months after non-surgical periodontal treatment | change in activator inhibitor 1 level (pg/mL) |
| change in C-reactive protein between baseline and 3 months after non-surgical periodontal treatment | 3 months after non-surgical periodontal treatment | change in C-reactive protein level (mg/L) |
| change in fibrinogen level between baseline and 6 months after non-surgical periodontal treatment | 6 months after non-surgical periodontal treatment | change in plasma fibrinogen level (pg/mL) |
| change in activator inhibitor 1 between baseline and 6 months after non-surgical periodontal treatment | 6 months after non-surgical periodontal treatment | change in activator inhibitor 1 level (pg/mL) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change of pocket depth between baseline and 6 months after non-surgical periodontal treatment | 6 months after non-surgical periodontal treatment | Depth of periodontal pocket in millimeters |
| change of bleeding on probing between baseline and 3 months after non-surgical periodontal treatment | 3 months after non-surgical periodontal treatment | percetage of sites with bleeding on probing |
| change of pocket depth between baseline and 3 months after non-surgical periodontal treatment | 3 months after non-surgical periodontal treatment | Depth of periodontal pocket in millimeters |
| change of clinical attachment level between baseline and 3 months after non-surgical periodontal treatment | 3 months after non-surgical periodontal treatment | Level of clinical attachment in millimeters |
| change of bleeding on probing between baseline and 6 months after non-surgical periodontal treatment | 6 months after non-surgical periodontal treatment | percetage of sites with bleeding on probing |
| change of clinical attachment level between baseline and 6 months after non-surgical periodontal treatment | 6 months after non-surgical periodontal treatment | Level of clinical attachment in millimeters |
Countries
Thailand
Outcome results
None listed