Depression
Conditions
Keywords
depression, electroconvulsive therapy, retinal nerve fiber layer, optical coherence tomography
Brief summary
The aim of this study is to investigate the changes in the retinal nerve fiber layer thickness of the patients with depression who received electroconvulsive therapy by means of optical coherence tomography.
Detailed description
Major depression (MD) is a mood disorder that is common in the society, has negative effects on emotion, thought and behavior, and leads to significant impairments in functionality. Electroconvulsive therapy (ECT) is a highly effective and reliable biological treatment method used in psychiatric diseases for a long time. The most common use in psychiatry is depression. Studies have shown that ECT causes a broadly distributed increase in brain gray matter volume (especially the temporal lobe) in MD patients. Optical coherence tomography (OCT) is a non-invasive medical imaging method that displays biological tissue layers by taking high resolution tomographic sections. Alterations in the thickness of the retinal nerve fiber layer (RNFL), which is a layer of the ganglion cell complex in the retina of the eye and consists of ganglion cell axons, occur due to axonal damage in the retinal nerve tissue. Since RNFL is in a similar form with the brain gray matter tissue, recently, neurological and psychiatric studies have been conducted to provide data regarding the neurodegeneration occurring in the brain tissue. In the study, it is aimed to assess the possible cortical volume changes of patients by measuring changes in the retinal layers due to ECT in patients with depression. In other words, considering that ECT causes an increase in brain volume, it is to observe whether this increase is reflected in the retinal nerve fiber layer thickness.
Interventions
DEVICEElectroconvulsive therapy
Thymatron System IV electroconvulsive therapy device
Sponsors
Mehmet Diyaddin Güleken
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Subject diagnosed as unipolar depression * Subject with depression to be treated with electroconvulsive therapy * Subject with depression having a Standardized Mini Mental Test score of \>23
Exclusion criteria
* Any comorbid psychiatric condition (including alcohol / substance use) * Having any major neurological (i.e.: cerebrovascular disease, multiple sclerosis, etc.) disease * Having any major medical (i.e.: diabetes mellitus, myocardial infarction, etc.) disease * History of or having any ocular trauma, disease or surgery, any retinal disease, refraction defect * To be treated with electroconvulsive therapy in the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of retinal nerve fiber layer thickness | About 4 weeks | Changes of retinal nerve fiber layer thickness of subjects with depression before and after electroconvulsive therapy |
Countries
Turkey (Türkiye)
Contacts
Primary ContactMehmet D Güleken, MD
Backup ContactHasan Öncül, MD
Outcome results
None listed