Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04304339

Acronym

YETI

Enrollment

862

Registered

2020-03-11

Start date

2021-12-14

Completion date

2022-07-13

Last updated

2025-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Failure, Hypercapnia, Intensive Care Unit Syndrome

Brief summary

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases. Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results. Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

Interventions

OTHERHypercapnic respiratory failure

Patients with hypercapnic respiratory failure will be followed without any additional intervention

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients ≥18 years old presenting with at least of the following items : 1. respiratory rate ≥ 25/min, 2. paradoxical motion of the abdomen, 3. intercostal retraction AND * a PaCO2 \> 45 cm H20 before ICU admission or within the 12 hours following ICU admission.

Exclusion criteria

* Refusal to give informed consent, * pregnancy, * \< 18 years patient, * dying patient

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of hypercapnic acute respiratory failure in ICU	Intensive Care Unit length stay (Usually 7 days)	Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026