Hip Arthroplasty, Transfusion
Conditions
Keywords
total hip arthroplasty, autologous blood donation
Brief summary
The investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized.
Detailed description
Total hip arthroplasty is procedure followed with large perioperative and postoperative blood loss. In order to avoid the application of large amounts of allogeneic blood, preoperative autologous blood donation as a tipe of autologous transfusion have been developed. In this study, the investigators studied the benefit of preoperative autologous blood donation in participants who undergo total hip arthroplasty. Study is made as a prospective and randomized. Participants were divided into three groups: the first group donated one dose of autologous blood 14 days preoperatively, the second group donated one dose of autologous blood 72 hours preoperatively and a third group was not donated autologous blood. The blood parameters, hemodynamic stability, bleeding, the need for application of autologous or homologous blood and length of hospital stay were compared.
Interventions
PROCEDUREPreoperative autologous blood donation, 14 days before surgery
PROCEDUREPreoperative autologous blood donation, 72 hours before surgery
PROCEDUREWithout preoperative blood donation
Sponsors
Clinical Hospital Centre Zagreb
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* subject older than 18 years * subject has primary coxarthrosis * subject has indication for total hip replacement
Exclusion criteria
* subject has secondary coxarthrosis * subject has need for revision endoprosthesis * history of autoimmune, malignancy or coagulation disorder * history of myocardial infarct or cerebrovascular insult in last 6 months * history of angina pectoris and unregulated hypertension * history of renal or liver failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patient red blood cells value | 6 days | analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day |
| Need for autologous blood transfusion | 6 days | Based on blood count and hemodynamic stability |
| Need for homologous blood transfusion | 6 days | Based on blood count and hemodynamic stability |
| Patient hemoglobin value | 6 days | analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day |
| Patient hematocrit value | 6 days | analysis of blood sample day before surgery, 3 hours after surgery, on first, second, fifth postoperative day and on sixth postoperative day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | 6 days | measure of length of hospital stay |
Outcome results
None listed