Nasopharyngeal Carcinoma, Head and Neck Cancer, Toxicity Due to Radiotherapy
Conditions
Brief summary
The primary purpose of this study is to explore the association of high sensitivity C-reactive protein (hsCRP) and radiotherapy(RT)-induced toxicity in patients with nasopharyngeal carcinoma. In each patient, hsCRP levels in the pre- and post-RT plasma samples will be measured according to the schedule we set.
Interventions
Only clinical parameters were recorded, no intervention was made.
Sponsors
Jiarong Chen, MD
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Inclusion criteria
* Patients were pathologically newly diagnosed with nasopharyngeal carcinoma and had no previous history of other tumors * According to the treatment strategies of doctors, patients need to receive radiotherapy with or without chemotherapy (for example, neoadjuvant chemotherapy, concurrent chemotherapy, adjuvant chemotherapy) or targeted therapy * Willingness to sign the informed consent and return to enrolling institution for follow-up and data collection
Exclusion criteria
* Patients do not conform to the inclusion criteria * Pregnant or Nursing women * Men or women of childbearing potential who are unwilling to employ adequate contraception * Vital organs dysfunction(for example, kidneys, heart, liver, lungs, brain) * Other contraindications or unsuitable conditions for radiotherapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of adverse events | Through treatments completion，12 weeks | All adverse events were recorded during treatment(for example, oral mucositis, dermatitis). |
| hsCRP levels | Through treatments completion，12 weeks | The hscrp levels in the plasma samples from each participant were measured at the following time points: 1. at the time of diagnosis completion/before the initiation of the first neoadjuvant chemotherapy 2. before the initiation of each neoadjuvant chemotherapy 3. before the initiation of the first radiotherapy 4. during radiotherapy, once a week 5. 1 week and 4weeks after the last radiotherapy |
Contacts
Primary ContactJiarong Chen, PhD
Backup ContactYanghao Ruan
Outcome results
None listed