Intracranial Neoplasm
Conditions
Brief summary
In this pilot study participants will undergo routine magnetic resonance imaging and routine neurosurgical care. By prospectively collecting data from both MRI and patient records we want to investigate biomarkers derived from tractography and diffusion tensor imaging to predict rehabilitation potential.
Detailed description
Patients will undergo MRI before and after surgery with DTI. With CSD-tractography, fiber bundles and their volumes will be identified. By measuring fractional anisotropy (FA) within these volumes, a correlation with clinical outcome and recovery will be tested. Also, FA frequency distributions will be used to describe white matter integrity and to thereby improve future tractography algorithms. Fiber bundles of interest will be the arcuate fascicle (AF), the corticospinal tract (CST), frontal aslant tract (FAT), the inferior fronto-occipital fascicle (IFOF), the inferior longitudinal fascicle (ILF) and the uncinate fascicle (UF).
Interventions
OTHERroutine MRI
MRI with routine DTI sequence
Sponsors
Tim Wende
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
* intracranial lesion * elective neurosurgical procedure
Exclusion criteria
* MRI not applicable * cerebral ischemia during study period * pregnancy during study period * encephalitis during study period * spontaneous intracerebral hemorrhage during study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurological Performance | three months | Neurological Performance Score (NPS) |
Countries
Germany
Outcome results
None listed