Coenzyme q10
Conditions
Keywords
ovulation induction, coenzyme q10, pregnancy rate
Brief summary
The study evaluates the effect of coenzyme q 10 on ovulation and subsequent pregnancy in women with polycystic ovarian syndrome. Half of the participants will receive coq10 and ovulation induction with clomiphene and other half would receive a placebo with clomiphene.
Interventions
DRUGCoenzyme Q10
antioxidant used to decrease oxidative stress and improve fertility prospects
DRUGclomiphene citrate
ovulation induction drug
Sponsors
Karachi Medical and Dental College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of polycystic ovarian syndrome PCOS based on the revised 2003 consensus on diagnostic criteria and long-term health risks related to PCOS (2003). * All women were previously treated with 100 mg of CC daily for 5 days per cycle, for two to three cycles with persistent anovulation or ovulate with very thin endometrium \<5 mm at the time of hCG administration
Exclusion criteria
* Non-consenting. * known autoimmune disorders * prior treatment of endometriosis or surgery to reproductive tract * prior history of pelvic inflammatory disease * those with tubal factors and uterine factors as assessed on history and confirmed by normal hysterosalpingogram. * Thyroid disorder as assessed by history examination and TSH level * Patients with raised FSH
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of ovulating women | 1-2 months | transvaginal ultrasound as the disappearance of the leading follicle, presence of follicular fluid in the Douglas pouch and midluteal progesterone \>5 pg/ml. |
| number of pregnancies | 1-2 months | ultrasound visualization of gestational sac with pulsating fetal pole |
Countries
Pakistan
Outcome results
None listed