Asthma, Occupational
Conditions
Brief summary
The project aims to increase the diagnostic accuracy in occupational asthma (OA), with emphasis on Irritant Induced Asthma (IIA). Currently, most patients are evaluated in occupational medicine by comparing the exposure and symptom characteristics with epidemiological data. Biological markers may be present in AA, but presently not in IIA. The majority of cases evaluated are considered as possible IIA, i.e. low-dose multiple exposures. VOC features will be analyzed with the Breath Biopsy® and TD-GS-MS (Owlstone Medical Ltd, UK).
Interventions
DEVICEBreath Biopsy
ReCIVA breath sampler (Owlstone Medical, Cambridge, UK)
Sponsors
Owlstone Ltd
Oslo University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* capable of informed consent. * asthma diagnosis established by lung specialist or healthy control.
Exclusion criteria
* skin allergy towards plastics or rubber. * immunocompromised by oral medication. * contagious respiratory disease. * biopsy of lung parenchyma within the last 36 hours.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Discovery of VOC Biomarkers in Asthma | Baseline | To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify asthma. |
| Discovery of VOC Biomarkers in Occupational Irritant Asthma | Baseline | To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify irritant asthma after occupational exposures. |
Countries
Norway
Contacts
Primary ContactBato Hammarström, MD/PhD
Backup ContactTonje Trulssen Hildre, M.Sc.
Outcome results
None listed