Procyanidin B2 Enriched Cocoa Effects on Mitochondrial Biogenesis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04301583

Acronym

PROMETHEO

Enrollment

Registered

2020-03-10

Start date

2020-06-01

Completion date

2020-09-01

Last updated

2020-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Athletes

Brief summary

The purpose of this study is to test how cocoa-rich procyanidin B2 affect the mitochondrial exercise adaptations.

Interventions

DIETARY_SUPPLEMENTprocyanidin B2 enriched cocoa

Volunteers will intake 5 grams per day of dietary supplement for 10 weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Masking description

Sachets

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Men/Women * Age between 18 and 45 years * Aerobic power of oxygen consumption greater than or equal to 55 mL / kg / min

Exclusion criteria

* Smoke * Any chronic disease * Intake of nutritional or ergogenic supplements * Chronic medication * Cocoa allergy

Design outcomes

Primary

Measure	Time frame	Description
Difference in mitochondrial number	10 weeks	Number of mitochondria in blood cells measured by qPCR using mitochondrial COX1 gene and beta globin as housekeeping nuclear gene
Difference in exercise performance	10 weeks	Maximum oxygen consumption * of incomplete pulmonary gas exchange on VO2 max - Powers - Citado por 318 * determination of cardiorespiratory fitness and training … - Clark - Citado por 180 Maximum oxygen consumption

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026