Chronic Kidney Disease
Conditions
Keywords
risk factors, omics, multidisciplinary care
Brief summary
CKD is a global endemic disease with increased comorbidities and mortality. The prevalence and the incidence of the end-stage renal disease (ESRD) are extremely high in Taiwan. Early diagnosis of disease and proper management remain challenging. The aims of this study are: 1. Explore risk factors associated with CKD 2. Establish multidisciplinary care model for CKD patients 3. Development cost-effective clinical care pathway for CKD 4. Provide bio-specimen repository for future study
Detailed description
CKD is a global endemic disease with increased comorbidities and mortality. The prevalence and the incidence of the end-stage renal disease (ESRD) are extremely high in Taiwan. Early diagnosis of disease and proper management remain challenging. The aims of this study are: 1. Explore risk factors associated with CKD: demographic, social and genetics factors 2. Establish multidisciplinary care model for CKD patients 3. Development cost-effective clinical care pathway for CKD 4. Provide bio-specimen repository for future study: serum, PBMC, urine and stool
Interventions
BEHAVIORALmultidisciplinary care
multidisciplinary CKD care involving case management nurse, dietitian, social worker, pharmacists.
Sponsors
Ministry of Science and Technology, Taiwan
Chang Gung Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects visiting outpatient clinics of nephrology of Chang Gung Memorial Hospital
Exclusion criteria
* Patient receiving dialysis or transplantation * Unwilling to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| percentage (%) | through study completion, every 1 year | percentage of patients with new CKD, starting dialysis treatments, cardiovascular event or mortality |
| difference of US dollars | through study completion, every 1 year | differences of US dollars of medical care (out patients and inpatients service fees) between groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| fold changes of proteins | through study completion, every 1 year | change of levels between groups |
| fold changes of microRNA | through study completion, every 1 year | change of levels between groups |
Other
| Measure | Time frame | Description |
|---|---|---|
| change of taxonomic units abundance of specific microbiota | through study completion, every 1 year | change of levels between groups |
| changes of metabolites | through study completion, every 1 year | change of levels between groups |
Countries
Taiwan
Contacts
Primary ContactTsang-Tang Hsieh
Outcome results
None listed