Infertility of Cervical Origin, Polymorphism, Restriction Fragment Length, Premature
Conditions
Brief summary
This study could help identify aggravating or protective genetic polymorphisms associated with cerebral palsy. Populations of premature babies at different risk of cerebral palsy could thus be individualized with an impact on their monitoring and on the pathophysiological understanding of the processes leading to neurological lesions.
Interventions
OTHERno intervention
no intervention
Sponsors
Nantes University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 12 Years
Inclusion criteria
* children born prematurely at term \<34 weeks between 2008 and 2015 * assessed at the age of 2 within the Growing Together Network in Pays de Loire * parental consent for the collection of data from their child and for intraoral sampling for the search for genetic factors.
Exclusion criteria
* children who died after the age of 2 * children who refused and / or whose parents refused to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identify a polymorphism associated with the risk of developing cerebral palsy at 2 years in a regional population of premature infants of gestational age <34 weeks gestation. | 2 years | frequency of variants within the case and control groups using the statistical criterion level of significance (also called p-value and known by the English word p-value) of 5.10-8 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identify a specific polymorphism of certain forms of cerebral palsy | 2 years | neurological examination |
| Develop a prognosis algorithm for the occurrence of cerebral palsy for personalized monitoring in a population at risk. | 2 years | neurological examination |
Countries
France
Outcome results
None listed