Attention Deficit Hyperactivity Disorder, Bipolar Disorder, Borderline Personality Disorder, Major Depressive Disorder, Schizophrenia, Substance Use Disorders, Traumatic Brain Injury
Conditions
Keywords
Transcranial Direct Current Stimulation, Executive Function
Brief summary
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.
Detailed description
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain. The investigators will select 8 relevant diagnostic categories: traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorder. The study will also include a cohort of healthy controls for comparison.
Interventions
DEVICETranscranial Direct Current Stimulation
In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes.
Sponsors
Massachusetts General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Male and female outpatients 18-65 years of age 2. A diagnosis of traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorders meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
Exclusion criteria
1. Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, shunts, pacemakers, pregnancy. 2. Active substance dependence (except for tobacco and cannabis). 3. Pregnant or nursing females. 4. Inability to participate in testing procedures. 5. Additional
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in N-Back Task | Baseline to Post-Treatment, 1 Week | Working Memory Task |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Flanker Task | Baseline to Post-Treatment, 1 Week | Attention and Inhibitory Control Task |
| Change in Multi-Source Interference with International Affective Picture System Task | Baseline to Post-Treatment, 1 Week | Cognitive Control During Emotional Regulation Task |
| Change in Delayed Discounting Task | Baseline to Post-Treatment, 1 Week | Decision-Making Task |
| Change in Stop Signal Task | Baseline to Post-Treatment, 1 Week | Ability to Inhibit a Response Task |
| Change in Iowa Gambling Task | Baseline to Post-Treatment, 1 Week | Risk-Taking Task |
Countries
United States
Contacts
Primary ContactJoan Camprodon, MD, PhD, MPH
Backup ContactPatricia Cirillo, MD, PhD
Outcome results
None listed