Endometriosis (Diagnosis), Identification of Biomarkers in Serum
Conditions
Brief summary
Background: Endometriosis, which is characterized by the growth of endometrial stroma and glands outside of the uterine cavity, is estimated to occur in 6-10% of women of reproductive age. Clinical presentation of endometriosis can vary widely, often significantly reducing quality of life, and the mean interval between the onset of symptoms and obtaining a definitive diagnosis is approximately 10 years. Currently, laparoscopy is the gold standard for diagnosing endometriosis; however, this procedure is invasive, carries surgery-related risks, and contributes to diagnostic delay. Therefore, the field has an urgent need for an efficient, sensitive, non-invasive tool for diagnosing endometriosis. Recently, it was shown that sVCAM-1/sICAM-1 ratio is a promising serum biomarker, which may lead to the development of a new, efficient, sensitive, non-invasive tool for diagnosing endometriosis, thereby potentially avoiding surgical interventions. Primary aim: To determine whether the serum sVCAM-1/sICAM-1 ratio can be used todiagnose endometriosis. Study design: Prospective multicenter validation study
Interventions
None listed
Sponsors
Medical-Scientific Fund of the Mayor of the Federal Capital Vienna
Heinrich Husslein
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* unfulfilled desire for children * chronic pelvic pain * suspicion of endometriosis * cysts * myomas
Exclusion criteria
* acute infections * malign diseases * drug abuse * pregnancy * infectious diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sICAM and sVCAM in serum | up to 1 week | levels of these two soluble adhesion factors in serum of patients and controls |
Countries
Austria
Contacts
Primary ContactLorenz Kuessel, Dr.
Outcome results
None listed