MRI
Conditions
Keywords
Magnetic Resonance Imaging, Image Post-Processing, Neuro-Radiology
Brief summary
The study's purpose is to validate STAGE images and, when applicable, their equivalence to conventional MRI through an assessment by a trained certified neuroradiologist in a clinical setting. For STAGE images without conventional equivalent, the neuroradiologist will determine if their contrasts, intensities, and quality are sufficient and meet expectations for images used in radiological reads of the brain. The study is a multi-center study in which STAGE can be assessed at sites with different MRI manufacturers and field strengths. Site names will be made available to the collaborators and participants. The sponsor is based out of Michigan, while participating sites may be located in other states. Any funding for the study will come from an industry source, SpinTech, Inc.
Detailed description
The scope of the study includes the acquisition of MR images from a specified MR manufacturer, the installation of the STAGE device at the clinical site, the subsequent processing of the acquired MR images, and their evaluation by neuroradiologists. The follow section will summarize the key procedures which are involved in this study. 1. Participants will be enrolled as study subjects per IRB approved protocol and informed consent. 2. The STAGE device will be installed at the clinical site. The installation of the Investigational STAGE module requires it to be labeled for Investigational Use Only, per FDA requirements. It requires an available power source and live Ethernet connection. STAGE is connected to the PACS via a node which requires the AE title and an assigned IP address. The node will only accept images which meet the STAGE protocol requirements and any other images are not used. After the images are processed and sent back to the PACS system, all data are purged from the STAGE module. A log is kept of which data was processed which can be viewed through the assigned IP within a web browser. All images under the study protocol shall be labeled For Investigational Device Use Only. 3. The PI and Co-Investigators will be trained on the use of installed STAGE investigational device. This will include a review of the installation and user manuals written as documentation under the FDA regulated development process. Documentation of the training process will be documented with data workflow and output images being presented. 4. After these steps the clinical study collection of MR images will begin. Since a primary aim of STAGE is to reduce acquisition times while generating a wealth of contrasts from the dataset, additional conventional MR images will be acquired including but not limited to: T1W, Susceptibility Weighted Images (SWI), Magnetic Resonance Angiography (MRA), and Spin Density Weighted (PDW). The patient's time in the magnet will be kept under 40 minutes. The STAGE protocol is available for Siemens, GE, Philips, and Canon/Toshiba magnets at both 1.5T and 3.0T field strengths. The processed STAGE images will be sent back to the PACS system where they remain within the participant's scan folder and are clearly labeled. They can then be viewed at an integrated workstation. 5. The study data will then be collected on Case Report Forms to record the response from the reading radiologist as well as the documented acquisition times for the STAGE protocol and the standard of care acquisition times used within that clinical setting (control arm of study). Prospective data will include imaging as well as questionnaire/survey with the radiologist to evaluate the performance of STAGE and its outputs. The study will not consist of retrospective data. 6. Clinical study completions and closeout. At the conclusion of the study, STAGE will be removed from the site by a trained technician and all data from the study will be purged from the PACS. A checklist will be documented to show that all measurable clinical response metrics have been recorded and that the study has successfully contributed its intended aims while following IRB and FDA regulations for clinical studies.
Interventions
DEVICESTrategically Acquired Gradient Echo (STAGE)
The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired.
Sponsors
Summit Medical Center
Center for Diagnostic Imaging
Loma Linda University
University of Texas Southwestern Medical Center
University of Iowa
University of Massachusetts, Worcester
SpinTech, Inc.
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Masking description
Study does not involve masking.
Intervention model description
All human participants in the study will be imaged using MRI under the same acquisition protocol. The STAGE protocol is collected alongside conventional MR.
Eligibility
Sex/Gender
ALL
Age
6 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects 6-80 years of age, inclusive. * Literate in English * No contraindications to MR * Not claustrophobic
Exclusion criteria
* Subject has diffuse white matter disease or leukoaraiosis. * Participant, or if participant is under 18 years of age, participant's parent or guardian unable to read and sign an informed consent. * Women who are pregnant or breast-feeding. * Those with major surgery within the past eight weeks or scheduled surgery within 30 days. * Chronic back pain or inability to lie still for 5 minutes or more. * History of drug or alcohol abuse. * Individuals who exceed 28 BMI or 320 lbs. * Individual whose girth exceeds the magnetic bore. * Direct employee or student of the PI. * Participants belong to a vulnerable group.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Baseline Only | Reading radiologists responses on the clinical usability of STAGE Outputs based on image quality using a numeric rating scale of 1 to 5 with: 1=unacceptable, 2=poor, 3=acceptable, 4=good, 5=excellent. Scores of 3 or greater are considered clinically usable. |
| Review of STAGE Outputs for Artifact and Image Contrast | Baseline Only | Reading radiologist and image analyst responses on the clinical usability of STAGE Outputs based on image quality using a yes/no criteria for presence of novel or accentuated imaging artifact. Hardware or participant artifact contributions (i.e. coil sensitivity and motion) were not considered unless noted as increased due to the STAGE method. Each image series was evaluated for the presence of artifact. The total count of the artifacts reported across series evaluated in the study is reported. |
| Review of STAGE Outputs for Expected Brain Structural Appearance | Baseline Only | Reading radiologists responses on the clinical usability of STAGE Outputs based on image appearance of specified brain structures using pass/fail criteria. Expected brain contrast between tissue types will vary depending on the output reviewed (i.e. T1W, PDW, SWI). The behavior of tissue contrasts (i.e. white matter vs gray matter) should also demonstrate standard anatomic contrast (T1W, PDW, SWI) as well quantitative ratio for maps (T2\*MAP, R2\*MAP, SWIM, T1MAP, PDMAP). For artery/vein appearance, STAGE T1W, T1MAP and PD MAP were not evaluated due to artery/vein not appearing in the image contrasts. For GM/WM/CSF, the MRA, pSWIM and mpSWIM were not evaluated due to the anatomic contrast not appearing in the image contrasts. For calcium/iron appearance, T1WE, T1MAP, PDMAP, MRA, and DIR were not evaluated due to the calcium/iron not appearing in the image contrasts. |
| Evaluation of STAGE Image Processing Times | Baseline Only | Review of the recorded processing times for the STAGE module to accept and process STAGE inputs and to export them back to the PACS as STAGE outputs. |
Countries
United States
Participant flow
Recruitment details
Subject recruitment took place across three sites and resulted in a total of 92 participant enrollment with 89 participants remaining after attrition. Recruitment took place between July 2020 and December 2020.
Participants by arm
| Arm | Count |
|---|---|
| STrategically Acquired Gradient Echo (STAGE) STAGE Inputs are flow compensated 3D gradient echo MR images acquired at optimal parameters which are used to calculate multiple contrasts for brain imaging. All subjects within the study are imaged using both a conventional MR protocol and STAGE protocol.
STrategically Acquired Gradient Echo (STAGE): The STAGE package uses conventional 3D gradient echo MR, its magnitude and phase, collected at set parameters which allow for the reconstruction of multiple MR datasets which results in decreased acquisition time, equivalency to conventional MR, and the decrease in scan time allows for a higher standard of wealth within the data acquired. | 92 |
| Total | 92 |
Baseline characteristics
| Characteristic | STrategically Acquired Gradient Echo (STAGE) | — |
|---|---|---|
| Age, Categorical <=18 years | 1 Participants | — |
| Age, Categorical >=65 years | 2 Participants | — |
| Age, Categorical Between 18 and 65 years | 89 Participants | — |
| Age, Continuous | 33.4 years STANDARD_DEVIATION 12.2 | — |
| Race and Ethnicity Not Collected | — | — Participants |
| Region of Enrollment United States | 92 participants | — |
| Sex: Female, Male Female | 53 Participants | — |
| Sex: Female, Male Male | 39 Participants | — |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 92 |
| other Total, other adverse events | 0 / 92 |
| serious Total, serious adverse events | 0 / 92 |
Outcome results
Primary
Evaluation of STAGE Image Processing Times
Review of the recorded processing times for the STAGE module to accept and process STAGE inputs and to export them back to the PACS as STAGE outputs.
Time frame: Baseline Only
Population: The average and minimum/maximum processing times for STAGE were evaluated across scanners, resolutions, and field strengths.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| STrategically Acquired Gradient Echo (STAGE) | Evaluation of STAGE Image Processing Times | 3T GE Signa Premier | 17.4 Time (minutes) | Standard Deviation 3.2 |
| STrategically Acquired Gradient Echo (STAGE) | Evaluation of STAGE Image Processing Times | 1.5T Siemens Aera | 7.6 Time (minutes) | Standard Deviation 0.8 |
| STrategically Acquired Gradient Echo (STAGE) | Evaluation of STAGE Image Processing Times | 3T Siemens Skyra | 10.1 Time (minutes) | Standard Deviation 1.7 |
| STrategically Acquired Gradient Echo (STAGE) | Evaluation of STAGE Image Processing Times | 3T Siemens Prisma | 11.3 Time (minutes) | Standard Deviation 2 |
Primary
Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs
Reading radiologists responses on the clinical usability of STAGE Outputs based on image quality using a numeric rating scale of 1 to 5 with: 1=unacceptable, 2=poor, 3=acceptable, 4=good, 5=excellent. Scores of 3 or greater are considered clinically usable.
Time frame: Baseline Only
Population: Scores of 3 or greater are considered clinically acceptable. The count of participants is presented for each score and for each STAGE output series.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional T1W Input Score=5 | 49 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional T1W Input Score=4 | 40 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional T1W Input Score=3 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional T1W Input Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional PDW Input Score=5 | 44 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional PDW Input Score=4 | 45 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional PDW Input Score=3 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional PDW Input Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional MPRAGE Score=5 | 49 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional MPRAGE Score=4 | 40 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional MPRAGE Score=3 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | Conventional MPRAGE Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1W Score=5 | 49 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1W Score=4 | 39 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1W Score=3 | 1 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1W Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PDW Score=5 | 36 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PDW Score=4 | 50 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PDW Score=3 | 3 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PDW Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Score=5 | 49 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Score=4 | 37 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Score=3 | 3 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Coronal Score=5 | 38 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Coronal Score=4 | 28 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Coronal Score=3 | 23 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Coronal Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Sagittal Score=5 | 44 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Sagittal Score=4 | 24 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Sagittal Score=3 | 21 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1We Sagittal Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1 MAP Score=5 | 48 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1 MAP Score=4 | 40 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1 MAP Score=3 | 1 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T1 MAP Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PD MAP Score=5 | 48 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PD MAP Score=4 | 39 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PD MAP Score=3 | 2 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE PD MAP Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE SWI Score=5 | 1 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE SWI Score=4 | 54 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE SWI Score=3 | 34 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE SWI Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE tSWI Score=5 | 3 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE tSWI Score=4 | 55 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE tSWI Score=3 | 31 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE tSWI Score=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE iSWIM Score=5 | 9 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE iSWIM Score=4 | 58 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE iSWIM Score=3 | 21 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE iSWIM Score<=2 | 1 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE R2* MAP Score=5 | 26 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE R2* MAP Score=4 | 35 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE R2* MAP Score=3 | 27 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE R2* MAP Score<=2 | 1 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T2* MAP Score=5 | 2 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T2* MAP Score=4 | 35 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T2* MAP Score=3 | 51 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE T2* MAP Score<=2 | 1 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE MRA Score=5 | 35 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE MRA Score=4 | 27 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE MRA Score=3 | 27 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE MRA Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE pSWIM Score=5 | 34 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE pSWIM Score=4 | 33 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE pSWIM Score=3 | 22 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE pSWIM Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE mpSWIM Score=5 | 36 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE mpSWIM Score=4 | 31 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE mpSWIM Score=3 | 22 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE mpSWIM Score<=2 | 0 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE DIR Score=5 | 45 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE DIR Score=4 | 21 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE DIR Score=3 | 22 Participants |
| STrategically Acquired Gradient Echo (STAGE) | Numeric Rating Scale of Clinical Usability Assessment of STAGE Outputs | STAGE DIR Score<=2 | 1 Participants |
Primary
Review of STAGE Outputs for Artifact and Image Contrast
Reading radiologist and image analyst responses on the clinical usability of STAGE Outputs based on image quality using a yes/no criteria for presence of novel or accentuated imaging artifact. Hardware or participant artifact contributions (i.e. coil sensitivity and motion) were not considered unless noted as increased due to the STAGE method. Each image series was evaluated for the presence of artifact. The total count of the artifacts reported across series evaluated in the study is reported.
Time frame: Baseline Only
Population: Reported number of observed artifacts within image series are shown as a count.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | Conventional T1MPRAGE | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | Conventional T1W | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | Conventional PDW | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE T1W | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE PDW | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE T1WE | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE T1MAP | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE PDMAP | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE SWI | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE tSWI | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE iSWIM | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE R2*MAP | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE T2*MAP | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE MRA | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE pSWIM | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE mpSWIM | 0 Artifact Count |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Artifact and Image Contrast | STAGE DIR | 0 Artifact Count |
Primary
Review of STAGE Outputs for Expected Brain Structural Appearance
Reading radiologists responses on the clinical usability of STAGE Outputs based on image appearance of specified brain structures using pass/fail criteria. Expected brain contrast between tissue types will vary depending on the output reviewed (i.e. T1W, PDW, SWI). The behavior of tissue contrasts (i.e. white matter vs gray matter) should also demonstrate standard anatomic contrast (T1W, PDW, SWI) as well quantitative ratio for maps (T2\*MAP, R2\*MAP, SWIM, T1MAP, PDMAP). For artery/vein appearance, STAGE T1W, T1MAP and PD MAP were not evaluated due to artery/vein not appearing in the image contrasts. For GM/WM/CSF, the MRA, pSWIM and mpSWIM were not evaluated due to the anatomic contrast not appearing in the image contrasts. For calcium/iron appearance, T1WE, T1MAP, PDMAP, MRA, and DIR were not evaluated due to the calcium/iron not appearing in the image contrasts.
Time frame: Baseline Only
Population: Image series were evaluated for 1) correct artery/vein appearance, 2) calcium/iron appearance, and 3) contrast between gray matter, white matter, and cerebrospinal fluid. Data were evaluated across all STAGE output images based on these structures appearance. The count of image series units is shown as either meeting criteria or not.
| Arm | Measure | Group | Category | Value (COUNT_OF_UNITS) |
|---|---|---|---|---|
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | Conventional T1MPRAGE Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | Conventional T1MPRAGE Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | Conventional T1W Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | Conventional T1W Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | Conventional PDW Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | Conventional PDW Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T1W Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T1W Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE PDW Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE PDW Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE SWI Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE SWI Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE tSWI Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE tSWI Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE iSWIM Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE iSWIM Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE R2*MAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE R2*MAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T2*MAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T2*MAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE MRA Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE MRA Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE pSWIM Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE pSWIM Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE mpSWIM Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE mpSWIM Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T1WE Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T1WE Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T1MAP Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE T1MAP Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE PDMAP Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE PDMAP Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE DIR Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Artery and Vein | STAGE DIR Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | Conventional T1MPRAGE Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | Conventional T1MPRAGE Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | Conventional T1W Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | Conventional T1W Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | Conventional PDW Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | Conventional PDW Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T1W Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T1W Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE PDW Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE PDW Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE SWI Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE SWI Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE tSWI Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE tSWI Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE iSWIM Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE iSWIM Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE R2*MAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE R2*MAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T2*MAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T2*MAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE MRA Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE MRA Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE pSWIM Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE pSWIM Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE mpSWIM Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE mpSWIM Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T1WE Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T1WE Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T1MAP Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE T1MAP Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE PDMAP Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE PDMAP Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE DIR Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Calcium and Iron | STAGE DIR Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | Conventional T1MPRAGE Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | Conventional T1MPRAGE Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | Conventional T1W Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | Conventional T1W Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | Conventional PDW Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | Conventional PDW Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T1W Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T1W Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE PDW Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE PDW Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE SWI Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE SWI Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE tSWI Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE tSWI Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE iSWIM Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE iSWIM Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE R2*MAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE R2*MAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T2*MAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T2*MAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE MRA Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE MRA Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE pSWIM Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE pSWIM Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE mpSWIM Criteria Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE mpSWIM Criteria Not Met | NA Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T1WE Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T1WE Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T1MAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE T1MAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE PDMAP Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE PDMAP Criteria Not Met | 0 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE DIR Criteria Met | 89 Image Series |
| STrategically Acquired Gradient Echo (STAGE) | Review of STAGE Outputs for Expected Brain Structural Appearance | Gray Matter / White Matter / Cerebrospinal Fluid | STAGE DIR Criteria Not Met | 0 Image Series |