Appetite; Perverted, Endocrine; Obesity, Obesity
Conditions
Keywords
Nutrient, Anorexigenic hormone, Calorific Intake
Brief summary
When a meal is eaten, nutrients activate the release of hormones from the bowel into the blood stream. Normally there is a large amount of hormone released, which tells the brain that an individual is full and to stop eating. When people gain weight and become overweight or obese, these hormone signals are reduced, resulting in these people eating more and gaining more weight. This study is investigating mechanisms which may break this cycle by using particular nutrients to restore reduced hormone levels.
Interventions
DIETARY_SUPPLEMENTLauric Acid, Perilla Oil and Diindolylmethane
Colonic release capsules containing lauric acid (2400mg), perilla oil (2100mg) and diinodlylmethane (500mg) given to volunteers 1 hour prior to standardised breakfast and lunch meal. Placebo group given cellulose capsules of same volume prior to standardised breakfast and lunch meal.
Sponsors
Queen Mary University of London
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Double blinded, randomised, crossover, placebo controlled.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Obese but otherwise healthy volunteers, * body mass index (BMI) of 30-40 kg/m2 * agreement to consume scheduled meals * ability to understand the study information sheet and instructions in English and able to provide informed consent.
Exclusion criteria
* Not meeting any of the
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect on appetite and satiety ratings | Study day 1 and study day 2 (following meal intake at breakfast and lunch) | Effect on appetite measured as change in calorific intake |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect on gut hormone levels | Study day 1 and study day 2 with samples taken every 30 min | Assess changes to circulating levels of anorectic hormones GLP-1, PYY and orexigenic hormone Ghrelin. |
| Effect on satiety scores | Study day 1 and study day 2 (following meal intake at breakfast and lunch) | Using a visual analogue scale measuring changes to hunger, satiety and fullness scores |
Countries
United Kingdom
Outcome results
None listed