Long Term Neurobehavioral Effects
Conditions
Keywords
infant, anesthesia, neurobehavioral development
Brief summary
The long-term effect of general anesthesia on developing brain is the focus of clinicians when infants exposed to general anesthesia for a long time during operation. A retrospective study showed that children exposed to long-term or repeated operations, the anesthetics had a higher incidence of cognitive impairment in adolescence than those did no. When infants with hearing impairment undergo bilateral cochlear implant surgery, they are at high risk of long-term neurobehavioral abnormalities caused by anesthesia. In this study, investigators intend to observe the long-term behavioral abnormalities of hearing-impaired infants after intravenous or inhalation anesthesia by a ambispective cohort study.
Detailed description
Gesell development scale contains five subscales including adaptability, fine motor, gross motor, language, and social skill evaluation. Developmental quotient (DQ) = (development age/actual age)×100. Total DQ is the average of five DQ of subscales. DQ≥86 is normal, 76≤DQ≤85 is suspicious, 55≤DQ≤75 is mild neurological damage, 40≤DQ ≤54 is moderate neurological damage, 25 B DQ B 39 is severe neurological damage, and DQ\< 25 is very severe neurological damage.
Interventions
None listed
Sponsors
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Months to 36 Months
Inclusion criteria
* Children undergoing cochlear implantation under general anesthesia * 6 to 36-month-old child * Normal body weight * Children with normal structures of the inner ear and auditory nerve * Children without contraindications to anesthesia and surgery * Patients who have not participated in other clinical trials * Without any acute infectious diseases or systematic diseases
Exclusion criteria
* The participants with a Gesell score (fine motor and gross motor) lower than 86 after preoperative evaluation. * With other illness which could affects curative effect of recovery, such as inner ear malformations (except for large vestibular aqueduct syndrome), auditory vestibular nerve dysplasia, dysgnosia and mental disease; * Inability to cooperate with the hearing evaluation and the language training * Cute and chronic otitis media and mastoiditis, unhealed tympanic membrane perforation * Abnormal structure of brain, including white matter dysplasia, Demyelinating Diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change of Baseline Gesell Developmental Scale after 6 month | change in 6 months after surgery] | Neurobehavior effects was measured use Gesell Developmental Scale. DQ (Developmental quotient) was calculated by (development age/actual age)×100. Total DQ is the average of five DQ of subscales. DQ≥86 is normal, 76≤DQ≤85 is suspicious, 55≤DQ≤75 is mild neurological damage, 40≤DQ≤54 is moderate neurological damage, 25≤DQ≤39 is severe neurological damage, and DQ \<25 is very severe neurological damage |
Countries
China
Outcome results
None listed