Human Single Neuron Recordings in Epilepsy Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04290416

Enrollment

Registered

2020-02-28

Start date

2016-02-04

Completion date

2021-12-31

Last updated

2020-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy, Memory

Brief summary

This study uses single neuron recordings in pre-surgical epilepsy patients to uncover the neural mechanisms underlying memory formation and retrieval. A secondary aim is to improve diagnostic tools to identify epileptogenic tissue.

Interventions

DIAGNOSTIC_TESTMicrowire electrodes

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Interest in participation. * Temporal lobe epilepsy that is clinically being investigated with implantations of depth electrodes as part of the pre-surgical epilepsy monitoring. * Cognitive/language skills sufficient to follow experimental instruction and maintain focus on the experiment.

Exclusion criteria

* Patient does not want to participate. * Extra-temporal epilepsy, or electrode implantation strategy that does not allow the use of micro-macrowire electrodes. * Cognitive/language skills insufficient to follow experimental instruction and maintain focus on the experiment.

Design outcomes

Primary

Measure	Time frame	Description
Single unit recordings	14 days (patient in hospital for this length of time)	Activity of individual neurons will be recorded via micro wire electrodes

Secondary

Measure	Time frame	Description
Intracranial electroencephalogram (iEEG)	14 days (patient in hospital for this length of time)	Secondary outcome measures will be iEEG signals recorded with the macro electrodes, such as: * Event-related potentials * EEG power and phase of Theta oscillations * EEG power and phase of Alpha/Beta oscillations * EEG power and phase of Gamma oscillations * EEG power of High Frequency Oscillations (\>80 Hz)
Behavioural response data	14 days (patient in hospital for this length of time)	Laptop button presses and corresponding response times will be recorded in MATLAB and presentation file formats. This is acquired at patient's bedside during hospital admission.

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026