Colorectal Cancer, Oncologic Complications and Emergencies
Conditions
Keywords
Complicated colorectal cancer, Curative resection, Surgical and oncologic outcomes
Brief summary
The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer
Detailed description
60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.
Interventions
PROCEDURECurative resection of colorectal cancer
Sponsors
University of Alexandria
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* All patients presented with Potentially operable colorectal cancer * No clinical or radiological evidence of metastatic disease
Exclusion criteria
* Patients received preoperative chemoradiation * Patients with clinical or radiological evidence of metastatic disease * Patients with intraoperative evidence of metastatic disease * Patients with intraoperative evidence of irresectable disease * Patients with incomplete follow up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adequate oncologic resection | histopathological assessment of surgical specimens within 2 weeks postoperative | Negative resection margins + adequate lymphadenectomy ( Lymph Nodes retrieved \> 12) |
| early postoperative mortality after curative resection of colorectal cancer | within 90 days after surgery | early death due to cause related to surgery |
| early postoperative morbidity after curative resection of colorectal cancer | within 90 days after surgery | surgery-related complications |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tumor recurrence | By the end of the 3 years follow up period | either local or distant |
| Disease free survival | By the end of the 3 years follow up period | % of patients survived without recurrence |
| Overall survival | By the end of the 3 years follow up period | % of all patients survived either with or without recurrence |
Outcome results
None listed