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Fetal Heart Rate Variability and Fetal Growth Restriction

Fetal Heart Rate Variability Compared to Doppler Flows in the Growth Restricted Fetus: a Cohort Study

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04288037
Acronym
(FGR)
Enrollment
40
Registered
2020-02-27
Start date
2019-05-01
Completion date
2020-12-01
Last updated
2020-11-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal Growth Retardation

Brief summary

There is growing evidence in the field of fetal heart rate variability revealing the fetal neurological state. Furthermore, fetal heart rate variability has shown potential as fetal surveillance in fetal growth restriction. This study aim to investigate the association between fetal heart rate variability and doppler flow changes in growth restricted fetuses.

Interventions

observational study. no intervention

Sponsors

Aarhus University Hospital
CollaboratorOTHER
Snedkermester Sophus Jacobsen and hustru Astrid Jacobsens Foundation
CollaboratorOTHER
Hartmann Fonden
CollaboratorOTHER
Augustinus Fonden
CollaboratorOTHER
The Dagmar Marshall Foundation
CollaboratorOTHER
AP Moeller Foundation
CollaboratorOTHER
University of Aarhus
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE

Inclusion criteria

* singleton pregnant women with estimated fetal weight below 2 standard deviations (2SD) of mean for gestational age corresponding to minus 22%. Fetal weight assessed by doppler ultrasound.

Exclusion criteria

* Fetal malformations

Design outcomes

Primary

MeasureTime frameDescription
Root mean square of successive inter beat interval differences RMSSD1/12-2020Time domain analysis
Standard deviation of normal to normal inter beat interval (SDNN)1/12-2020Time domain analysis
Low frequency power (LF-power)1/12-2020Spectral analysis
High frequency power (HF-power)1/12-2020Spectral analysis
Low frequency power/High frequency power (LF/HF)1/12-2020Spectral analysis

Countries

Denmark

Contacts

Primary ContactAnne Rahbek Zizzo, MD
arz@clin.au.dk+45 7845 3325

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026