Anxiety State, Nausea, Vomiting
Conditions
Keywords
anxiety, hematopoietic stem cell transplantation, inhalation aromatherapy, nausea, randomized controlled trial
Brief summary
Patients undergoing stem cell transplantation for the first time will be entered. Participants will be randomized to one of two study arms: Arm 1: intervention (routine care+ inhalation aromatherapy); Arm 2: Control (Routine care) Hypotheses: (1) Patients receiving inhalation aromatherapy will experience less severe nausea and less frequent vomiting episodes than those receiving only routine care; and (2) patients receiving inhalation aromatherapy will demonstrate lower anxiety levels just after AHSCT than those receiving only routine care.
Detailed description
Earlier research indicates that aromatherapy is promising to relieve in DMSO related nausea and anxiety in autologous stem cell transplant patients. The current study seeks to confirm and extend these findings in a 2-arm, open-label randomized, controlled study of 70 cancer patients undergoing autologous stem cell transplantation. All patients will receive a standardized premedication. Arm 1: Intervention (inhalation aromatherapy with orange essential oil during stem cell infusion); Arm 2: Control (routine care). The researchers hypothesize that inhalation aromatherapy with orange essential oil will be effective in reducing DMSO related nausea and vomiting and demonstrate lower anxiety levels just after autologous stem cell transplantation.
Interventions
OTHERInhalation aromatherapy with orange essential oil
Sponsors
Hacettepe University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \> 18 years, * the absence of any mental conditions including depression, anxiety disorders, psychotic disorders or dementia that may affect the patients' communication abilities
Exclusion criteria
* Patients with chronic obstructive pulmonary disease or asthma, * a history of allergy to orange or orange essential oil, * presence of persistent nausea and vomiting due to conditioning regimens, * receiving antiemetic other than routine premedication, * patients undergoing AHSCT for the second or more time were excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in nausea severity | At 1st minute of each stem cell infusion bag | Patient report Nausea severity will be assessed based on patient report by using a visual analog scale. The patients will be asked to rate their nausea severity and place a mark on the scale from 0 to 10. |
| change in number of vomiting | From 1st minute of the stem cell infusion to completion of the intervention | Observation Number of vomiting and retching episodes will be observed by the researcher who apply aromatherapy and recorded in a vomiting and retching episodes form. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| anxiety | Through stem cell infusion completion, an avarege of 30 minutes | Patient report State Anxiety Inventory will be used to measure anxiety level. |
Outcome results
None listed