Severe Aortic Stenosis, TAVI
Conditions
Brief summary
Severe aortic valve stenosis is known to affect heart haemodynamics, endothelial function and body inflammation markers. Our aim is to investigate the weather transcatheter aortic valve implantation in patients with severe aortic stenosis affects heart rate variability, inflammation markers and endothelial function.
Interventions
DIAGNOSTIC_TESTFlow mediated vasodilatation
Measurement of brachial artery diameter change before and after limb ischaemia.
DIAGNOSTIC_TESTHigh resolution ECG
Measurement HRV using high resolution ECG
DIAGNOSTIC_TESTBlood withdrawal
Measurement of endothelial inflammation markers
Sponsors
University Medical Centre Ljubljana
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* TAVI
Exclusion criteria
* stage V chronic kidney disease * active malignancies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of heart rate variability | 3 to 6 months after TAVI | Change of heart rate variability (HRV) estimated with digital high resolution ECG recording |
| Change of laboratory value of endothelial inflammation markers | 3 to 6 months after TAVI | Laboratory determined numerical changes in endothelial inflammation markers |
| Change of flow-mediated filatation (FMD) of the brachial artery | 3 to 6 months after TAVI | % flow-mediated dilatation |
Countries
Slovenia
Outcome results
None listed